{"id":"W3136091920","doi":"10.1212/wnl.94.15_supplement.4757","title":"A Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of Two Formulations of a Novel Nav1.6 Sodium Channnel Blocker (XEN901) in Healthy Adult Subjects. (4757)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Tolerability; Pharmacokinetics; Medicine; Pharmacology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341299,0.001239055,0.00176241,0.000216976,0.0003181184,0.0007043781,0.0006050153,0.001066241,0.005264372],"category_scores_gemma":[0.0009669694,0.0005391259,0.001048215,0.0002099219,0.0006189381,0.0008944167,0.0002974558,0.002537509,0.0009734413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006073794,"about_ca_system_score_gemma":0.001373508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000864387,"about_ca_topic_score_gemma":0.001932629,"domain_scores_codex":[0.999482,0.000242545,0.00002330344,0.0001099362,0.00005492342,0.00008726934],"domain_scores_gemma":[0.9993462,0.000116403,0.0001597867,0.0000675606,0.00005767021,0.0002524017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7245267,0.08226745,0.005094763,0.0006760738,0.001728942,0.0002970005,0.000255777,0.001203263,0.1001593,0.0004237109,0.004090465,0.07927655],"study_design_scores_gemma":[0.261085,0.719224,0.01020064,0.00002246717,0.000518767,0.0003474096,0.0000699477,0.0007800704,0.005118064,0.000179776,0.002412093,0.00004174968],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990364,0.001456247,0.001369626,0.0002947033,0.0001643902,0.002849551,0.001722108,0.0001093613,0.001669978],"genre_scores_gemma":[0.9805838,0.001820418,0.004311652,0.001450107,0.0002789826,0.003490016,0.003086585,0.00006061057,0.004917812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005264372,"threshold_uncertainty_score":0.01761109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08184040407294658,"score_gpt":0.403076488155125,"score_spread":0.3212360840821784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}