{"id":"W3136113179","doi":"10.1016/j.ejca.2021.02.022","title":"Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report","year":2021,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; European Regional Development Fund; Manchester Biomedical Research Centre; Parc Geneteg Cymru; National Institutes of Health; Centro de Investigación Biomédica en Red de Cáncer; Syöpäsäätiö; Sigrid Juséliuksen Säätiö; Jane ja Aatos Erkon Säätiö; Instrumentariumin Tiedesäätiö; Ministerio de Sanidad, Servicios Sociales e Igualdad; Emil Aaltosen Säätiö; Ministero della Salute; KWF Kankerbestrijding; Ministerio de Economía y Competitividad; LOEWE Zentrum AdRIA; Deutsche Krebshilfe; National Institute for Health and Care Research; Generalitat de Catalunya; Kreftforeningen; Suomen Lääketieteen Säätiö; Academy of Finland; Centres de Recerca de Catalunya; Health and Care Research Wales","keywords":"Hysterectomy; Medicine; Lynch syndrome; Oophorectomy; Gynecology; General surgery; Surgery; Internal medicine; DNA mismatch repair; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001179695,0.0002064828,0.0007696543,0.00022266,0.00002151408,0.00001087977,0.0001291347,0.00004430255,0.0002656511],"category_scores_gemma":[0.0005197534,0.0001758622,0.0002033852,0.0004933117,0.0001416821,0.0001067246,0.0001067711,0.0003893554,8.989249e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786096,"about_ca_system_score_gemma":0.0008700612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006574066,"about_ca_topic_score_gemma":0.00004969698,"domain_scores_codex":[0.9973077,0.0002893662,0.001295408,0.0003430519,0.0005189988,0.0002454367],"domain_scores_gemma":[0.9977582,0.00005594661,0.0008333891,0.0004190376,0.0007420622,0.0001914104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0017619,0.0002972369,0.5345316,0.0009546126,0.0009612687,0.03804609,0.004139869,0.00008295909,0.4126931,0.000008440342,0.0008327811,0.005690146],"study_design_scores_gemma":[0.004108029,0.001074885,0.940942,0.002292362,0.0003145231,0.01511783,0.00055677,0.00003831168,0.03330003,0.00001907238,0.002035322,0.0002008032],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901298,0.007424915,0.00004333872,0.0001458679,0.0006194808,0.0002629407,0.00005819893,0.00001130039,0.001304181],"genre_scores_gemma":[0.9945517,0.0005687937,0.004360961,0.000075192,0.0001194803,0.000005226867,0.00000511132,0.000052084,0.0002614748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4064105,"threshold_uncertainty_score":0.717145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516537633760049,"score_gpt":0.2756392994169821,"score_spread":0.2604739230793816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}