{"id":"W3136113179","doi":"10.1016/j.ejca.2021.02.022","title":"Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report","year":2021,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; European Regional Development Fund; Manchester Biomedical Research Centre; Parc Geneteg Cymru; National Institutes of Health; Centro de Investigación Biomédica en Red de Cáncer; Syöpäsäätiö; Sigrid Juséliuksen Säätiö; Jane ja Aatos Erkon Säätiö; Instrumentariumin Tiedesäätiö; Ministerio de Sanidad, Servicios Sociales e Igualdad; Emil Aaltosen Säätiö; Ministero della Salute; KWF Kankerbestrijding; Ministerio de Economía y Competitividad; LOEWE Zentrum AdRIA; Deutsche Krebshilfe; National Institute for Health and Care Research; Generalitat de Catalunya; Kreftforeningen; Suomen Lääketieteen Säätiö; Academy of Finland; Centres de Recerca de Catalunya; Health and Care Research Wales","keywords":"Hysterectomy; Medicine; Lynch syndrome; Oophorectomy; Gynecology; General surgery; Surgery; Internal medicine; DNA mismatch repair; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004935897,0.0001508465,0.0002008609,0.0008718358,0.0002119298,0.0004152307,0.0003138713,0.0003408478,0.001239713],"category_scores_gemma":[0.002189544,0.0002254583,0.0003385431,0.001076166,0.0001367494,0.0002872307,0.000414905,0.0003010781,0.0002078042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238806,"about_ca_system_score_gemma":0.0002482798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01225617,"about_ca_topic_score_gemma":0.01325876,"domain_scores_codex":[0.9994965,0.0001232477,0.0000828768,0.0001509239,0.00008850504,0.00005787256],"domain_scores_gemma":[0.998032,0.0003427737,0.001170527,0.0001299198,0.0001441035,0.0001806771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001989356,0.000004008368,0.9994067,0.000005977728,0.00001894602,0.00003050483,0.00001656395,0.000009184176,0.00005389471,0.000003349877,0.00005254477,0.000378506],"study_design_scores_gemma":[0.000002833659,0.00002034829,0.9994066,0.000005677903,0.00002060479,0.0002408182,0.00007881955,0.00008698708,0.00003372632,0.000003222584,0.00009851786,0.000001761746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974729,0.0003288119,0.000040928,0.00004345675,0.000003790855,0.00000577682,0.001856068,0.000002769907,0.0002454823],"genre_scores_gemma":[0.9985363,0.0001866613,0.00006315648,0.00002097815,0.000005432699,0.000005272251,0.00111649,0.000001424243,0.00006413367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01225617,"threshold_uncertainty_score":0.02436966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516537633760049,"score_gpt":0.2756392994169821,"score_spread":0.2604739230793816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}