{"id":"W3136150419","doi":"10.1186/s13287-021-02245-5","title":"Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury","year":2021,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Core Research for Evolutional Science and Technology; Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine","keywords":"Mesenchymal stem cell; Transfection; Transgene; Genetic enhancement; Biology; Stem cell; Gene delivery; Immunology; Cell biology; Medicine; Cancer research; Molecular biology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006012835,0.0009661235,0.0005954726,0.001045982,0.0001794299,0.000536486,0.0004294684,0.0009138863,0.001706542],"category_scores_gemma":[0.0002012333,0.0003151054,0.0005525361,0.000413139,0.0007630028,0.0006077031,0.0002023772,0.00163965,0.0005450719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342145,"about_ca_system_score_gemma":0.0004579727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006159824,"about_ca_topic_score_gemma":0.0007161904,"domain_scores_codex":[0.9994071,0.00006673286,0.00006847063,0.0001501583,0.0002066735,0.0001008682],"domain_scores_gemma":[0.9996302,0.00005360276,0.0001372993,0.00002738994,0.00004613054,0.0001053317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001878675,0.0001166306,0.00007050914,0.00005897477,0.000006588928,0.00002762442,0.00002103307,0.00006131447,0.9980665,0.0001143822,0.00003731476,0.001231341],"study_design_scores_gemma":[0.00004977528,0.001731019,0.001002846,0.00001287338,0.00003968011,0.000153245,0.00001774011,0.0006266593,0.9948249,0.00003589442,0.001497594,0.000007662461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748065,0.003614637,0.01739944,0.0005024608,0.0002376501,0.000251167,0.001060262,0.0005571762,0.001570757],"genre_scores_gemma":[0.964312,0.003591267,0.02328353,0.0002108837,0.00007033706,0.0004082225,0.001448341,0.0001710843,0.006504253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706542,"threshold_uncertainty_score":0.005708933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03064913827547273,"score_gpt":0.2969100952253901,"score_spread":0.2662609569499174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}