{"id":"W3136180086","doi":"10.21926/obm.genet.2101127","title":"Current Progress in Cancer Immunotherapies Using Small Molecules Targeting PD-L1 Stability","year":2021,"lang":"en","type":"article","venue":"OBM Genetics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Cure Brain Cancer Foundation","keywords":"PD-L1; Immune system; Immune checkpoint; Cancer research; Tumor microenvironment; Immunotherapy; Context (archaeology); Monoclonal antibody; Cancer immunotherapy; Small molecule; Nivolumab; Biology; Antibody; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008695219,0.0005730024,0.0007259166,0.001018968,0.0002033923,0.0009489589,0.0005172118,0.0007199232,0.001727831],"category_scores_gemma":[0.0004441075,0.0002601309,0.0005152143,0.0009117384,0.0003498979,0.001136307,0.000425581,0.0009858063,0.0008083335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000629409,"about_ca_system_score_gemma":0.000691908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769536,"about_ca_topic_score_gemma":0.0005072907,"domain_scores_codex":[0.9998044,0.00003941853,0.00002946101,0.00004651251,0.00005416095,0.00002608822],"domain_scores_gemma":[0.9997081,0.0001491938,0.00005554478,0.00001228252,0.00005409276,0.00002072412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003234762,0.000179621,0.000537525,0.009824978,0.0001092457,0.0002261023,0.0001250572,0.001123555,0.04070209,0.004837737,0.005843302,0.9361672],"study_design_scores_gemma":[0.0001196432,0.001674424,0.002341925,0.001669958,0.000466463,0.002230156,0.0001349464,0.001250148,0.05156003,0.003732341,0.9347519,0.00006802585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004466373,0.9906433,0.001762156,0.0005384107,0.000134214,0.00001817933,0.00004462488,0.00004626498,0.002346467],"genre_scores_gemma":[0.01950205,0.9764617,0.001822891,0.0004204155,0.0002502324,0.00004560267,0.0001708372,0.00001071922,0.001315445],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001727831,"threshold_uncertainty_score":0.00578016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05590190399020994,"score_gpt":0.3370238142511775,"score_spread":0.2811219102609676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}