{"id":"W3136187347","doi":"10.3390/biom11030482","title":"Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Dictyostelium discoideum","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Trent University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Dalhousie University","keywords":"Neddylation; NEDD8; Dictyostelium discoideum; Multicellular organism; Cell biology; Biology; Chemotaxis; Dictyostelium; Biochemistry; Cell; Ubiquitin; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206355,0.0002947469,0.0003154832,0.0001653313,0.0001107885,0.0001702609,0.0002165418,0.0002320485,0.0004497227],"category_scores_gemma":[0.00009693951,0.0001272995,0.0002249554,0.0001127345,0.0001649633,0.0001323397,0.0001621523,0.0003844214,0.000168581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135059,"about_ca_system_score_gemma":0.0002369649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525961,"about_ca_topic_score_gemma":0.002536293,"domain_scores_codex":[0.9998993,0.00001397776,0.00001727785,0.00001769312,0.00002628805,0.00002538486],"domain_scores_gemma":[0.9999295,0.00001337021,0.000019484,0.000006751142,0.000007201887,0.00002377442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273887,0.00002052858,0.0001723201,0.00003672361,0.000003514951,0.00002495652,0.000009008105,0.00004727455,0.9988468,0.00002634137,0.00004694819,0.0006381106],"study_design_scores_gemma":[0.00004223609,0.0005504872,0.006332912,0.000004872044,0.00001369872,0.00009323082,0.00002157933,0.001132862,0.989447,0.00002056317,0.002335971,0.000004626464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943727,0.002685166,0.0009354709,0.0001038054,0.00004282555,0.00002650122,0.0004880322,0.00007906687,0.001266336],"genre_scores_gemma":[0.9960652,0.0007680931,0.00100151,0.00007205888,0.000006640354,0.00003717255,0.0004790377,0.00001151047,0.001558644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525961,"threshold_uncertainty_score":0.003034115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390365835668445,"score_gpt":0.2175086529112932,"score_spread":0.2081182870756247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}