{"id":"W3136187347","doi":"10.3390/biom11030482","title":"Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Dictyostelium discoideum","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Trent University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Dalhousie University","keywords":"Neddylation; NEDD8; Dictyostelium discoideum; Multicellular organism; Cell biology; Biology; Chemotaxis; Dictyostelium; Biochemistry; Cell; Ubiquitin; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000973646,0.0001564003,0.0001187477,0.00004766575,0.00007974311,0.00005341931,0.00006542235,0.00009372349,0.000007431933],"category_scores_gemma":[0.00008529943,0.0001405625,0.00002231574,0.000119837,0.00008337685,0.000007989201,0.000135599,0.00006271734,0.00000298142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008951831,"about_ca_system_score_gemma":0.0001139303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003331962,"about_ca_topic_score_gemma":0.0002376379,"domain_scores_codex":[0.999024,0.00006841167,0.0001924803,0.0003671286,0.0001192138,0.0002287686],"domain_scores_gemma":[0.9996548,0.00001549595,0.00005579703,0.0001376657,0.0000661575,0.00007011411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004624456,0.00003999274,0.011814,0.00006905364,0.00002014616,0.00007254074,0.0002204745,0.000005058188,0.9857606,0.0002283853,0.00001340716,0.001710071],"study_design_scores_gemma":[0.0005876628,0.00007770803,0.003515881,0.00008150568,0.000008454569,0.00004958883,0.0002967466,0.00004651693,0.9936437,0.00002985574,0.001442938,0.000219465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924988,0.002237403,0.003960851,0.0001884949,0.00002926263,0.000148919,0.00001061751,0.00001362603,0.0009120231],"genre_scores_gemma":[0.9918677,0.0001149278,0.007470893,0.0001190945,0.00005401028,0.00003132963,0.0002393887,0.00002254918,0.00008015608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00829812,"threshold_uncertainty_score":0.5731973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390365835668445,"score_gpt":0.2175086529112932,"score_spread":0.2081182870756247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}