{"id":"W3136216847","doi":"10.1038/s41380-021-01052-x","title":"Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; School of Medicine, University of California, San Diego; University of California, San Diego","keywords":"Haploinsufficiency; Neurogenesis; RHOA; Biology; Cell biology; Actin cytoskeleton; Mutant; Cytoskeleton; Neuroscience; Phenotype; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008934858,0.0003413637,0.0001739134,0.0004207095,0.0002052718,0.0002767106,0.0001988368,0.0002984577,0.001299654],"category_scores_gemma":[0.0001002824,0.0001319472,0.0002362937,0.0001414652,0.0003097768,0.0001359567,0.0002541116,0.0004388069,0.0002121696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004029872,"about_ca_system_score_gemma":0.000341144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00231937,"about_ca_topic_score_gemma":0.004512677,"domain_scores_codex":[0.9998769,0.000009889003,0.00001190541,0.00003197663,0.00003491023,0.00003443435],"domain_scores_gemma":[0.9998934,0.00001416196,0.00004395158,0.000008244832,0.000008560745,0.00003157184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005787482,0.000007395744,0.000573749,0.00001787923,0.00000611419,0.000176363,0.000009064731,0.00008212299,0.9980268,0.0001283442,0.00003965668,0.0008747264],"study_design_scores_gemma":[0.00001433314,0.00006451949,0.01918163,0.00001031376,0.00002603139,0.0009070017,0.00005255426,0.001289753,0.9762568,0.0001169744,0.002072686,0.000007388097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946107,0.0006245367,0.002270678,0.00009439909,0.00001371296,0.00001149113,0.0008515354,0.0001098841,0.001413041],"genre_scores_gemma":[0.9966587,0.0003349992,0.001084903,0.00003218098,0.000001866608,0.00001260581,0.0002912823,0.00002601799,0.001557366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00231937,"threshold_uncertainty_score":0.00461179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004960637741219185,"score_gpt":0.2741306444872448,"score_spread":0.2691700067460256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}