{"id":"W3136239322","doi":"10.3390/microorganisms9030620","title":"Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up?","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Unfolded protein response; Degron; RNA splicing; Intron; Saccharomyces cerevisiae; Translation (biology); Biology; Cell biology; Endoplasmic reticulum; Genetics; Gene; Messenger RNA; Ubiquitin ligase; Ubiquitin; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686833,0.0003267384,0.0004798449,0.000154942,0.0001435158,0.0007892956,0.0002958355,0.0003544392,0.0008161332],"category_scores_gemma":[0.0003994674,0.0001904709,0.0003376194,0.0002702222,0.0002422705,0.0002565112,0.0005218531,0.000589984,0.0007433656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264909,"about_ca_system_score_gemma":0.0002651105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016276,"about_ca_topic_score_gemma":0.001461837,"domain_scores_codex":[0.9996693,0.00003043177,0.00004726428,0.0001037377,0.00009969272,0.00004953074],"domain_scores_gemma":[0.9996191,0.00006462734,0.0001038203,0.00009607027,0.00005632265,0.00005996327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212702,0.00003494356,0.0008208008,0.00006961523,0.0000121148,0.0001027423,0.0000250149,0.00007736084,0.9955788,0.0001468054,0.0001077502,0.002902712],"study_design_scores_gemma":[0.00002229081,0.0002999392,0.0202148,0.00002129025,0.00004931445,0.0006887768,0.0001767097,0.0027655,0.9668802,0.0002488769,0.008607265,0.00002503498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895075,0.00125421,0.00428084,0.0002412796,0.00007544909,0.00003959009,0.00268577,0.000298125,0.001617228],"genre_scores_gemma":[0.992734,0.0004698705,0.001625326,0.0001815594,0.000008568871,0.00002897455,0.003621363,0.0001315182,0.001198815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016276,"threshold_uncertainty_score":0.00273025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007679016103957529,"score_gpt":0.2221400348262908,"score_spread":0.2144610187223333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}