{"id":"W3136284751","doi":"10.3389/fcell.2021.626095","title":"How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Tyrosine phosphorylation; CD28; Phosphorylation; Receptor tyrosine kinase; Tyrosine kinase; Biology; T-cell receptor; T cell; Proto-oncogene tyrosine-protein kinase Src; ZAP70; Receptor; Signal transduction; CD8; Immunological synapse; Immune system; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001185182,0.0003961437,0.0005630989,0.0008243623,0.0004631066,0.00290124,0.0003443016,0.002038897,0.003098337],"category_scores_gemma":[0.001984974,0.0003143426,0.0005556817,0.0004368111,0.001717061,0.003624598,0.001042167,0.004695213,0.001544585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001742459,"about_ca_system_score_gemma":0.0008332573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990278,"about_ca_topic_score_gemma":0.0005785482,"domain_scores_codex":[0.9995294,0.0001052288,0.00003097262,0.0001133949,0.0001294898,0.00009153006],"domain_scores_gemma":[0.9994618,0.000152499,0.00004888279,0.0000409061,0.0001695676,0.0001264161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007690311,0.0003844943,0.003024292,0.00149008,0.0001631443,0.001545705,0.0006224033,0.001935728,0.09766376,0.2795944,0.05875059,0.5540564],"study_design_scores_gemma":[0.0001413945,0.000475032,0.002412451,0.0004219884,0.0000807876,0.001588013,0.0003488382,0.001424905,0.04431831,0.0665698,0.8821241,0.00009447864],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1027332,0.599957,0.03205051,0.1373498,0.05067343,0.0002440531,0.0006567396,0.0007181023,0.07561713],"genre_scores_gemma":[0.533718,0.3053425,0.02299182,0.04323019,0.01899215,0.000272653,0.0005850428,0.0002587325,0.0746088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003098337,"threshold_uncertainty_score":0.01264244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083973058654245,"score_gpt":0.2338667972817008,"score_spread":0.2130270666951583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}