{"id":"W3136404423","doi":"10.3389/fcell.2021.641404","title":"Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"Sharjah Research Academy","keywords":"Wnt signaling pathway; Autocrine signalling; Paracrine signalling; LRP5; Biology; Cell biology; Immunology; LRP6; Signal transduction; Cancer research; Cell culture; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481891,0.0002193368,0.0002481922,0.0002900533,0.0002033198,0.0003537693,0.00008278615,0.0003408396,0.001210784],"category_scores_gemma":[0.0001525803,0.000209191,0.0004520982,0.0002221824,0.000161816,0.000137426,0.0001438212,0.00027558,0.0003974599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757558,"about_ca_system_score_gemma":0.0002108346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173853,"about_ca_topic_score_gemma":0.001480086,"domain_scores_codex":[0.9997867,0.00002668294,0.00002098264,0.00004383476,0.0000859092,0.00003587022],"domain_scores_gemma":[0.999905,0.00001477007,0.00003535943,0.00001073939,0.00001439176,0.00001964049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124958,0.000008970551,0.003101768,0.00006709511,0.00001347942,0.0003377683,0.00002407012,0.00009493617,0.9944969,0.00006933673,0.00003394846,0.001639248],"study_design_scores_gemma":[0.00003053147,0.0003885913,0.1500477,0.00005511137,0.0001054942,0.005114188,0.0003345831,0.002859773,0.8305855,0.0002927424,0.01016167,0.00002418635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906744,0.003855021,0.002561433,0.00008973961,0.00002739191,0.0000272169,0.0009896039,0.00007625841,0.001698807],"genre_scores_gemma":[0.9921164,0.002106568,0.002142753,0.00005899288,0.000006463064,0.00003151728,0.001268827,0.00001273387,0.002255659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210784,"threshold_uncertainty_score":0.004050434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005683024818423676,"score_gpt":0.2061101853678524,"score_spread":0.2004271605494288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}