{"id":"W3136421332","doi":"10.1101/2021.03.24.436822","title":"Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University Health Centre; McGill University","keywords":"Methylation; Arginine; HEK 293 cells; Methyltransferase; Biology; Viral replication; Protein arginine methyltransferase 5; Viral protein; Downregulation and upregulation; Viral life cycle; RNA; Molecular biology; Cell biology; Virology; Cell culture; Genetics; Amino acid; Gene; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009055604,0.0001876843,0.0001982364,0.00009563909,0.0001278959,0.0002333845,0.0001195298,0.0002028649,0.001019286],"category_scores_gemma":[0.00009847805,0.00009774885,0.000225731,0.00008237045,0.0001407657,0.0001340454,0.0001398705,0.0003179771,0.0004254202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406219,"about_ca_system_score_gemma":0.0001248032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006864961,"about_ca_topic_score_gemma":0.0007330938,"domain_scores_codex":[0.9998739,0.000020565,0.00001133356,0.00003403982,0.00003359592,0.00002651449],"domain_scores_gemma":[0.9999309,0.000008147832,0.00002517235,0.0000067171,0.000009816003,0.00001929766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005639171,0.000005962013,0.0001484362,0.000006532703,0.000001287615,0.00001147614,0.00000281647,0.00001569842,0.9994961,0.00001486786,0.00001101392,0.0002293553],"study_design_scores_gemma":[0.000008606579,0.0001082315,0.009741456,0.000002213785,0.000005439714,0.0001244137,0.00001483081,0.001074744,0.9878571,0.00002407951,0.001035691,0.000003295263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963631,0.001303721,0.001209532,0.00005527922,0.00001664042,0.00001180978,0.0002726718,0.0000564943,0.000710736],"genre_scores_gemma":[0.9975304,0.0002068141,0.0008841864,0.00002049423,0.00000457563,0.000007783957,0.0003083682,0.000009614764,0.001027823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019286,"threshold_uncertainty_score":0.003409922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125321771265913,"score_gpt":0.2304018398972356,"score_spread":0.2191486221845765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}