{"id":"W3136459518","doi":"10.1002/jbmr.4286","title":"Compressive Strength of Iliac Bone ECM Is Not Reduced in Osteogenesis Imperfecta and Increases With Mineralization","year":2020,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Fonds de Recherche du Québec - Santé; Shriners Hospitals for Children; Mereo BioPharma; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Osteogenesis imperfecta; Iliac crest; Mineralization (soil science); Nanoindentation; Extracellular matrix; Type I collagen; Compressive strength; Chemistry; Materials science; Biomedical engineering; Composite material; Anatomy; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005011671,0.0001031957,0.0002921323,0.0002140082,0.00004379814,0.00002517089,0.00008367149,0.0000746801,0.00002485033],"category_scores_gemma":[0.0008000076,0.0000817534,0.00004066166,0.0002813694,0.0001825812,0.00001494998,0.0001552086,0.0001997147,2.979786e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001140514,"about_ca_system_score_gemma":0.000171596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005104252,"about_ca_topic_score_gemma":0.0002890301,"domain_scores_codex":[0.9986315,0.0002219195,0.0003096221,0.0002123893,0.0004028439,0.0002217306],"domain_scores_gemma":[0.998889,0.00009289166,0.000122297,0.000110803,0.0006119066,0.0001730551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002130907,0.0001018719,0.01756488,0.00009497329,0.00005339556,0.00005135856,0.0003976316,0.00001256095,0.9741186,0.00001308556,0.001515669,0.003945001],"study_design_scores_gemma":[0.005601484,0.006960149,0.06845967,0.0002190737,0.00003641548,0.0001927721,0.002052226,0.0006054466,0.9128698,0.00003487315,0.002705926,0.0002621606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932749,0.004858507,0.00001353203,0.001561847,0.000005529295,0.0001670219,0.00002397654,8.463365e-7,0.00009386989],"genre_scores_gemma":[0.9972224,0.002233548,0.0001822495,0.00007420523,0.00008501951,0.000004856613,0.00001400018,0.00001366066,0.0001701229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06124887,"threshold_uncertainty_score":0.3333807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04007192498678868,"score_gpt":0.3363427865263023,"score_spread":0.2962708615395137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}