{"id":"W3136465602","doi":"10.1186/s13063-021-05165-0","title":"The time is now: role of pragmatic clinical trials in guiding response to global pandemics","year":2021,"lang":"en","type":"review","venue":"Trials","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Clinical trial; Pandemic; Medicine; Toll; Randomized controlled trial; Livelihood; Clinical research; Coronavirus disease 2019 (COVID-19); Intensive care medicine; Disease; Pathology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6893466,0.0004931337,0.02030939,0.0004270774,0.0001440116,0.00019363,0.00100046,0.0008856492,0.000436781],"category_scores_gemma":[0.575893,0.0004305335,0.002462184,0.0008091871,0.00008375043,0.0001424077,0.0002435089,0.0003587477,0.003781653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001175471,"about_ca_system_score_gemma":0.002184367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451728,"about_ca_topic_score_gemma":0.00006436813,"domain_scores_codex":[0.7790107,0.1185555,0.09870613,0.002065615,0.0004358815,0.00122624],"domain_scores_gemma":[0.7443746,0.2208814,0.03211601,0.00204837,0.000182033,0.0003975899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009556816,0.0004581005,0.001082818,0.01348958,0.002826106,0.000007349181,0.001413405,0.00003158949,9.605686e-7,0.04099572,0.3339411,0.6047976],"study_design_scores_gemma":[0.001010743,0.00008100674,0.00004334423,0.006303057,0.0001971239,0.000005236811,0.0001595417,0.00009430893,2.052874e-7,0.004973476,0.9867612,0.0003707617],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002391475,0.9805508,0.000139295,0.008367133,0.001470989,0.005826258,0.002531251,0.00002610089,0.0008490193],"genre_scores_gemma":[0.000008937724,0.9939108,0.001225915,0.002051917,0.001094089,0.0005732532,0.00006950148,0.00006060112,0.001004973],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6528201,"threshold_uncertainty_score":0.9998146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8547847867084332,"score_gpt":0.6500160712256531,"score_spread":0.2047687154827801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}