{"id":"W3136470136","doi":"10.1021/acschembio.1c00036","title":"The Promise and Peril of Chemical Probe Negative Controls","year":2021,"lang":"en","type":"letter","venue":"ACS Chemical Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Phenotype; Chemical biology; Ligand (biochemistry); Chemical modification; Computational biology; Target protein; Gene; Loss function; Chemistry; Function (biology); Biology; Biophysics; Genetics; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001718744,0.000311064,0.0005056669,0.00001646869,0.00005345756,0.00002629536,0.0003539875,0.001453572,0.00005361448],"category_scores_gemma":[0.0005222097,0.0002120258,0.0001712462,0.00005150859,0.0005432693,0.000001583719,0.0003360933,0.0007018643,0.000001879642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001386742,"about_ca_system_score_gemma":0.0001154767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008263003,"about_ca_topic_score_gemma":5.240728e-7,"domain_scores_codex":[0.9983339,0.0001391071,0.0003942888,0.0006199355,0.0001061934,0.0004065277],"domain_scores_gemma":[0.9989235,0.0002012916,0.0002331388,0.0004050391,0.0001770601,0.00006001215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008056467,0.0000150152,0.00001669772,0.00004477833,0.0001609612,0.0000060839,0.00002013166,2.622835e-8,0.9548942,0.0001357262,0.04338337,0.001242462],"study_design_scores_gemma":[0.0004138349,0.0001076455,4.706384e-7,0.00002279131,0.00003520292,0.00002530537,0.00001602193,0.000002686959,0.7613871,0.001048608,0.2367479,0.0001924425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8310937,0.01291846,0.0003008636,0.1522445,0.0006945064,0.001357581,0.000300855,0.00003496571,0.001054481],"genre_scores_gemma":[0.7756949,0.002712741,0.00384488,0.2004347,0.009490846,0.0005961889,0.005076697,0.0002161206,0.001932903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1935071,"threshold_uncertainty_score":0.9998428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00968408167549901,"score_gpt":0.23258081880757,"score_spread":0.2228967371320709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}