{"id":"W3136508589","doi":"10.1016/j.cell.2021.03.026","title":"BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"National Health and Medical Research Council; Deutsche Forschungsgemeinschaft; Australian Research Council; QIMR Berghofer Medical Research Institute","keywords":"Biology; Inflammation; Bromodomain; Cytokine storm; Cardiac dysfunction; Immunology; Myocarditis; Cytokine; HMGB1; Viral Myocarditis; Virus; Internal medicine; Coronavirus disease 2019 (COVID-19); Heart failure; Gene; Medicine; Infectious disease (medical specialty); Disease; Acetylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763547,0.0005535387,0.0005600407,0.0003200568,0.0003047518,0.0004389029,0.0002885572,0.0003970231,0.002335906],"category_scores_gemma":[0.000166899,0.0001712855,0.0003273636,0.0002348419,0.0003150723,0.0002549524,0.0001616632,0.001262044,0.0005593187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076457,"about_ca_system_score_gemma":0.0003605607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005222993,"about_ca_topic_score_gemma":0.001420531,"domain_scores_codex":[0.9998137,0.00003203823,0.00001690155,0.00002418723,0.00003376039,0.00007940033],"domain_scores_gemma":[0.9999293,0.00001141708,0.00001655684,0.00000810558,0.000008193637,0.00002633999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004619113,0.000684376,0.0003260533,0.0001804653,0.00005404251,0.0001061283,0.00002808677,0.0004622779,0.9843598,0.0007116631,0.0008870113,0.00758092],"study_design_scores_gemma":[0.0006552265,0.002860368,0.008073014,0.00004214689,0.000101433,0.0004044125,0.0000957434,0.002716122,0.9702013,0.0003300904,0.01449722,0.00002296759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825785,0.006560002,0.002415824,0.0005970134,0.0003833575,0.00009715534,0.001220363,0.0002507319,0.005897028],"genre_scores_gemma":[0.9879951,0.003238008,0.001649452,0.0001778976,0.00007905942,0.0001000507,0.001237647,0.00003315105,0.005489654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335906,"threshold_uncertainty_score":0.007814407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115273077099616,"score_gpt":0.2303323790153184,"score_spread":0.2191796482443223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}