{"id":"W3136508589","doi":"10.1016/j.cell.2021.03.026","title":"BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"National Health and Medical Research Council; Deutsche Forschungsgemeinschaft; Australian Research Council; QIMR Berghofer Medical Research Institute","keywords":"Biology; Inflammation; Bromodomain; Cytokine storm; Cardiac dysfunction; Immunology; Myocarditis; Cytokine; HMGB1; Viral Myocarditis; Virus; Internal medicine; Coronavirus disease 2019 (COVID-19); Heart failure; Gene; Medicine; Infectious disease (medical specialty); Disease; Acetylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008965132,0.00009030131,0.00007534507,0.00003300271,0.00008194614,0.00003747662,0.00001575908,0.0001149498,0.00001233817],"category_scores_gemma":[0.00004621132,0.00009868985,0.000041612,0.00008552341,0.00001817233,0.000009948972,0.00004254458,0.00006707859,0.00001733073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001530281,"about_ca_system_score_gemma":0.0000447466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002919905,"about_ca_topic_score_gemma":0.00003143733,"domain_scores_codex":[0.9994136,0.00005340565,0.0001319494,0.0002251844,0.00007725677,0.00009857057],"domain_scores_gemma":[0.9996471,0.000003905785,0.00005601467,0.0001581493,0.0001057682,0.00002902578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008534224,0.00001548833,0.0007594432,0.00001443751,0.000008868004,9.690043e-7,0.00001882743,0.000002312515,0.9935002,0.00001868133,0.00269306,0.002959212],"study_design_scores_gemma":[0.000303682,0.00006741384,0.001613965,0.000007963497,0.0000122208,0.000004815138,0.00001610183,0.00001934268,0.9517527,0.0000610456,0.04603018,0.0001105226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937505,0.0002024395,0.000787971,0.0001390032,0.0003630971,0.0001172715,0.000004831608,0.00002041293,0.004614439],"genre_scores_gemma":[0.9981961,0.0001677908,0.0001116839,0.0001391605,0.000405891,0.00001938187,0.000376722,0.00001090829,0.000572352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04333712,"threshold_uncertainty_score":0.4024455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115273077099616,"score_gpt":0.2303323790153184,"score_spread":0.2191796482443223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}