{"id":"W3136623417","doi":"10.1177/17448069211000910","title":"Differential modulation of thermal preference after sensitization by optogenetic or pharmacological activation of heat-sensitive nociceptors","year":2021,"lang":"en","type":"article","venue":"Molecular Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institute of Neurosciences, Mental Health and Addiction; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Optogenetics; Nociceptor; TRPV1; Neuroscience; Sensory system; Sensitization; Nociception; Noxious stimulus; Chronic pain; Medicine; Pharmacology; Psychology; Transient receptor potential channel; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101988,0.0001104193,0.0002067218,0.00003703365,0.00001627366,0.000003992969,0.00001865716,0.00008761702,0.0002992288],"category_scores_gemma":[0.00009716804,0.00008746369,0.00006956848,0.0001313425,0.00002851409,0.00002611681,0.00002052279,0.00005490587,0.000001407944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000366908,"about_ca_system_score_gemma":0.00004746577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268573,"about_ca_topic_score_gemma":0.000001001952,"domain_scores_codex":[0.9989252,0.0003593852,0.0001930943,0.000192541,0.0002176031,0.0001121765],"domain_scores_gemma":[0.9995503,0.00006741052,0.00006585205,0.0001089102,0.0001586216,0.00004894254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004684721,0.0003238724,0.001829844,0.00004620834,0.0001440997,0.00004990705,0.0001081026,0.0002481598,0.9933376,0.00002588275,0.000009712814,0.003408113],"study_design_scores_gemma":[0.001123198,0.0002913184,0.03562773,0.00007865593,0.0001332444,0.000004250448,0.00002781786,0.01368449,0.9489207,0.00003408037,0.000004275058,0.00007028026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.859297,0.00002688665,0.1402189,0.0001136623,0.00002515968,0.0002416909,0.00001227093,0.000009439224,0.00005488911],"genre_scores_gemma":[0.9976448,0.0000102537,0.001765548,0.000196322,0.00001807083,0.00001787209,0.000241059,0.00001289121,0.00009316901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1384534,"threshold_uncertainty_score":0.3566666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588011543261646,"score_gpt":0.2621788258323521,"score_spread":0.2462987103997357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}