{"id":"W3136631970","doi":"10.1016/j.jcin.2021.01.024","title":"Effect of CYP2C19 Genotype on Ischemic Outcomes During Oral P2Y12 Inhibitor Therapy","year":2021,"lang":"en","type":"review","venue":"JACC: Cardiovascular Interventions","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital; University of Ottawa; Heart and Stroke Foundation; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"P2Y12; CYP2C19; Medicine; Genotype; Internal medicine; Clopidogrel; Biology; Aspirin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.001438085,0.001000579,0.007197339,0.0004190427,0.0001612993,0.00004962684,0.0003868492,0.0006174913,0.0005284516],"category_scores_gemma":[0.0001873912,0.0007371034,0.05385417,0.0006954944,0.0001403606,0.0001033671,0.0001869646,0.0008812881,0.0002248667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286383,"about_ca_system_score_gemma":0.0002391767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000209211,"about_ca_topic_score_gemma":8.114847e-7,"domain_scores_codex":[0.9944932,0.001486992,0.001335078,0.001002418,0.001150864,0.0005314328],"domain_scores_gemma":[0.9964725,0.0001973833,0.000389498,0.002453485,0.0002371317,0.000249935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001690574,0.0004537069,0.0001914248,0.04907234,0.08830184,0.0007079051,0.00001735068,0.0000103227,0.00001175623,0.00001487848,0.0003162678,0.8607332],"study_design_scores_gemma":[0.005060974,0.0008583673,0.0004887835,0.06663388,0.032511,0.0006743933,0.0000213368,3.60706e-7,0.001255909,8.672597e-7,0.8917832,0.0007108721],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02204657,0.9741226,0.00008515914,0.000009424257,0.0007801775,0.002160934,0.000129641,0.0001578806,0.0005075729],"genre_scores_gemma":[0.00489391,0.9923257,0.00005173838,0.00001808065,0.0004460229,0.0004707027,0.0006397031,0.0002241708,0.0009299315],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.891467,"threshold_uncertainty_score":0.999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04870494635805145,"score_gpt":0.367007035469202,"score_spread":0.3183020891111505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}