{"id":"W3136631970","doi":"10.1016/j.jcin.2021.01.024","title":"Effect of CYP2C19 Genotype on Ischemic Outcomes During Oral P2Y12 Inhibitor Therapy","year":2021,"lang":"en","type":"review","venue":"JACC: Cardiovascular Interventions","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital; University of Ottawa; Heart and Stroke Foundation; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"P2Y12; CYP2C19; Medicine; Genotype; Internal medicine; Clopidogrel; Biology; Aspirin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009145841,0.0006770607,0.003329416,0.0008536836,0.0001162724,0.0007377375,0.0008006732,0.000873136,0.003387139],"category_scores_gemma":[0.002399519,0.0002358469,0.002637175,0.001347664,0.0002107458,0.0003684585,0.0003188183,0.001264028,0.0003662024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003278758,"about_ca_system_score_gemma":0.0006855218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002024289,"about_ca_topic_score_gemma":0.003637134,"domain_scores_codex":[0.9996425,0.0001059955,0.00007475702,0.00005416488,0.00009335471,0.00002929845],"domain_scores_gemma":[0.998949,0.0007454507,0.0001909893,0.00001438431,0.0000756283,0.00002452287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0034888,0.0001905417,0.003569569,0.1010936,0.01438882,0.0002036221,0.00006253304,0.0005712122,0.0008181469,0.0007475783,0.01315699,0.8617086],"study_design_scores_gemma":[0.009994614,0.005499969,0.1455715,0.1482971,0.1994923,0.003848059,0.0003891563,0.002119107,0.002193726,0.005030136,0.4772372,0.0003272337],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007953005,0.9987451,0.00003770649,0.00006712473,0.00006142957,0.000004252431,0.00003056295,0.00000235394,0.0002561177],"genre_scores_gemma":[0.009760264,0.9893907,0.0001718945,0.0001934675,0.0002072755,0.00001349723,0.00008908936,0.000002161013,0.0001716751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003387139,"threshold_uncertainty_score":0.01133114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04870494635805145,"score_gpt":0.367007035469202,"score_spread":0.3183020891111505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}