{"id":"W3136648532","doi":"10.1182/blood.2020009165","title":"MARCKS affects cell motility and response to BTK inhibitors in CLL","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; Ministry of Science and Higher Education of the Russian Federation; Genome Canada; Skolkovo Institute of Science and Technology; Deutsche Forschungsgemeinschaft; Megagrants; José Carreras Leukämie-Stiftung; National Heart, Lung, and Blood Institute; Gilead Sciences","keywords":"Bruton's tyrosine kinase; IGHV@; MARCKS; Chronic lymphocytic leukemia; Phosphorylation; Ibrutinib; Biology; Tyrosine phosphorylation; Cancer research; Protein kinase B; Idelalisib; breakpoint cluster region; Signal transduction; B-cell receptor; Tyrosine kinase; Cell biology; Protein kinase C; Immunology; Biochemistry; B cell; Leukemia; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362547,0.0002245598,0.0003295647,0.0002828692,0.0002343006,0.0003050329,0.00007993366,0.0002779512,0.001071575],"category_scores_gemma":[0.0001765146,0.0001134036,0.0002365777,0.0002499693,0.0001606922,0.0001493283,0.0001795028,0.0004287243,0.0002610362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040031,"about_ca_system_score_gemma":0.0001925467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300559,"about_ca_topic_score_gemma":0.001357798,"domain_scores_codex":[0.9998073,0.00002989959,0.00001669469,0.00002494572,0.00002941525,0.00009169462],"domain_scores_gemma":[0.9998833,0.00001420309,0.000030257,0.000007022009,0.00001360116,0.00005159361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008414422,0.00006925259,0.00161747,0.0000301329,0.000006556974,0.0000693166,0.00002646609,0.00004582872,0.995828,0.00001771358,0.00008037694,0.00136756],"study_design_scores_gemma":[0.00008555759,0.001983807,0.1232757,0.00001442612,0.00004197781,0.0006411449,0.0002019417,0.001409864,0.8694581,0.00004733535,0.002823134,0.0000170143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980881,0.001049348,0.0001148771,0.00006308666,0.00001884295,0.000007052045,0.0002339057,0.00002377268,0.000401051],"genre_scores_gemma":[0.9979596,0.0005568666,0.0001970403,0.00004499013,0.00001050833,0.00002147142,0.0003896795,0.000005159795,0.0008146867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300559,"threshold_uncertainty_score":0.003584743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104168312762224,"score_gpt":0.2761495664808537,"score_spread":0.2657327352046313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}