{"id":"W3136648532","doi":"10.1182/blood.2020009165","title":"MARCKS affects cell motility and response to BTK inhibitors in CLL","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; Ministry of Science and Higher Education of the Russian Federation; Genome Canada; Skolkovo Institute of Science and Technology; Deutsche Forschungsgemeinschaft; Megagrants; José Carreras Leukämie-Stiftung; National Heart, Lung, and Blood Institute; Gilead Sciences","keywords":"Bruton's tyrosine kinase; IGHV@; MARCKS; Chronic lymphocytic leukemia; Phosphorylation; Ibrutinib; Biology; Tyrosine phosphorylation; Cancer research; Protein kinase B; Idelalisib; breakpoint cluster region; Signal transduction; B-cell receptor; Tyrosine kinase; Cell biology; Protein kinase C; Immunology; Biochemistry; B cell; Leukemia; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007578972,0.0001164731,0.000242044,0.0001327442,0.00002812008,0.00002302911,0.0000679815,0.0001069031,0.00008586534],"category_scores_gemma":[0.001057252,0.0001105514,0.00004252742,0.0004218956,0.00005342327,0.00002517675,0.0002252695,0.0002193102,0.00006288906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001616444,"about_ca_system_score_gemma":0.003712161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001513342,"about_ca_topic_score_gemma":0.0001365735,"domain_scores_codex":[0.9985031,0.0002175139,0.0001664883,0.000389594,0.0003612751,0.0003620456],"domain_scores_gemma":[0.9987996,0.0003838957,0.00001769666,0.0004399825,0.00005915368,0.0002997351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008035756,0.007549007,0.1865741,0.00239625,0.0001590077,0.02780115,0.005814248,0.00002112904,0.7417042,0.00003530224,0.008784486,0.01112531],"study_design_scores_gemma":[0.06018467,0.0006026166,0.2296672,0.0003466628,0.00007624415,0.0006383354,0.0004377988,0.0003572435,0.7034521,0.00005285215,0.003969432,0.0002147871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948525,0.0008697972,0.000002003561,0.0009997862,0.00005682469,0.0003899028,0.000005244138,0.00003022971,0.002793641],"genre_scores_gemma":[0.9968686,0.00002977394,0.0004144174,0.0003117878,0.00008790689,0.00002210397,0.00000438763,0.00002015416,0.0022409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05214892,"threshold_uncertainty_score":0.6585214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104168312762224,"score_gpt":0.2761495664808537,"score_spread":0.2657327352046313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}