{"id":"W3136668322","doi":"10.1016/j.biopsych.2021.03.017","title":"Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Jewish General Hospital; Montreal General Hospital; McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University","keywords":"Psychology; Neuroscience; Hippocampus; Offspring; Neuroimaging; Neurodevelopmental disorder; Striatum; Internal medicine; Endocrinology; Biology; Autism; Medicine; Pregnancy; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243417,0.0005241143,0.0003552784,0.0007851476,0.0002967768,0.0004806927,0.0003303325,0.0006417744,0.001594374],"category_scores_gemma":[0.0001761014,0.000282688,0.000429248,0.0002618578,0.0007527059,0.0003590642,0.0003861567,0.001498143,0.0002567637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007392308,"about_ca_system_score_gemma":0.0004950011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002309778,"about_ca_topic_score_gemma":0.007376153,"domain_scores_codex":[0.9997922,0.00001937871,0.00001025507,0.00008438931,0.00003212409,0.00006165076],"domain_scores_gemma":[0.9997075,0.00002500735,0.0001236209,0.0000288985,0.00002997152,0.00008505819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196406,0.0001748034,0.004198924,0.0000355427,0.00002640259,0.000142402,0.00009498477,0.0000706452,0.9908687,0.0002398342,0.0001160382,0.002835309],"study_design_scores_gemma":[0.0001098603,0.002084937,0.1487438,0.00007061766,0.0002723731,0.0006619017,0.0009145657,0.001149075,0.840957,0.0007165776,0.004258173,0.00006126364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918283,0.0009959984,0.003776911,0.0002851091,0.00005794437,0.00003118718,0.002051036,0.0001115302,0.0008620469],"genre_scores_gemma":[0.9802546,0.002091809,0.005993744,0.0004022421,0.00002069405,0.0002705769,0.001554278,0.0001724635,0.009239651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309778,"threshold_uncertainty_score":0.005363524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05201827152513249,"score_gpt":0.305781257801338,"score_spread":0.2537629862762055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}