{"id":"W3136680349","doi":"10.1371/journal.ppat.1009473","title":"Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"H2020 Marie Skłodowska-Curie Actions; InflaRx; National and Kapodistrian University of Athens; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Commission; Angelini Pharma; AbbVie; National Research Foundation; XBiotech; Deutsche Forschungsgemeinschaft; Astellas Pharma; Astellas Pharma US","keywords":"Pseudomonas aeruginosa; Cystathionine beta synthase; Sepsis; In vivo; Cyclophosphamide; Microbiology; Medicine; Chemistry; Immunology; Pharmacology; Biology; Bacteria; Enzyme; Internal medicine; Chemotherapy; Biochemistry; Cysteine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957783,0.0003029552,0.0005294033,0.0001601403,0.0001141837,0.0002608663,0.0001757429,0.0002642371,0.0008883728],"category_scores_gemma":[0.0001805053,0.0001070766,0.0001900306,0.0000901345,0.0002176573,0.0001592136,0.000248813,0.0005644724,0.000207531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009219773,"about_ca_system_score_gemma":0.0002196242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215547,"about_ca_topic_score_gemma":0.000359915,"domain_scores_codex":[0.9999086,0.00002566716,0.000008342648,0.00001102368,0.00001560941,0.00003081578],"domain_scores_gemma":[0.9998457,0.00001428947,0.00003194056,0.00001714996,0.00001203582,0.00007882532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005360336,0.0006540004,0.001235979,0.00009264171,0.00002852356,0.00009858658,0.00004617167,0.00009700012,0.9812577,0.00004528277,0.0001760692,0.01090764],"study_design_scores_gemma":[0.001180838,0.05528187,0.0643733,0.0000957688,0.000181992,0.001036179,0.0002741182,0.002421503,0.869129,0.0002251341,0.005770653,0.00002960363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981451,0.001006655,0.0002981241,0.00009059517,0.00002164052,0.00002212572,0.00005625563,0.00005111393,0.000308375],"genre_scores_gemma":[0.9981722,0.0005924083,0.0002681648,0.00005747011,0.00002031634,0.00002501942,0.000162563,0.000006252464,0.0006955797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008883728,"threshold_uncertainty_score":0.002971947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577211528697188,"score_gpt":0.2373712481979021,"score_spread":0.2215991329109303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}