{"id":"W3136680349","doi":"10.1371/journal.ppat.1009473","title":"Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"H2020 Marie Skłodowska-Curie Actions; InflaRx; National and Kapodistrian University of Athens; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Commission; Angelini Pharma; AbbVie; National Research Foundation; XBiotech; Deutsche Forschungsgemeinschaft; Astellas Pharma; Astellas Pharma US","keywords":"Pseudomonas aeruginosa; Cystathionine beta synthase; Sepsis; In vivo; Cyclophosphamide; Microbiology; Medicine; Chemistry; Immunology; Pharmacology; Biology; Bacteria; Enzyme; Internal medicine; Chemotherapy; Biochemistry; Cysteine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001794246,0.0003821833,0.00036287,0.0000706003,0.0002088045,0.00004391259,0.0003602984,0.0003806714,0.00007256846],"category_scores_gemma":[0.0006710668,0.0003944148,0.0002518038,0.0002583745,0.0001582146,0.000005958779,0.0004306819,0.000222669,0.0001325987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005008013,"about_ca_system_score_gemma":0.0003072412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006084016,"about_ca_topic_score_gemma":0.00003735931,"domain_scores_codex":[0.9975063,0.0002911786,0.0003941224,0.0009351196,0.0002299631,0.0006433785],"domain_scores_gemma":[0.9982437,0.00004644191,0.0001505538,0.001012785,0.0003136265,0.0002329223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006762121,0.000224231,0.003539972,0.00003260007,0.0002141897,0.0004946488,0.0001080311,0.00003367098,0.9941152,0.00003064216,0.0005132093,0.0006259675],"study_design_scores_gemma":[0.0007832823,0.0001812422,0.001102469,0.00003145586,0.00004947444,0.000181631,0.0001505567,0.00009288749,0.9843737,0.00006902686,0.01249445,0.0004898171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949973,0.001502899,0.0004045886,0.0003686858,0.00023551,0.0004271842,0.0002159614,0.00008377546,0.001764115],"genre_scores_gemma":[0.9906109,0.0004487288,0.005348612,0.001441883,0.0004669158,0.0001747851,0.0008763628,0.00007949271,0.0005522968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01198124,"threshold_uncertainty_score":0.9998507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577211528697188,"score_gpt":0.2373712481979021,"score_spread":0.2215991329109303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}