{"id":"W3136696547","doi":"10.1016/bs.acr.2021.02.002","title":"mTOR as a senescence manipulation target: A forked road","year":2021,"lang":"en","type":"article","venue":"Advances in cancer research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institut Du Cancer de Montréal; Terry Fox Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"PI3K/AKT/mTOR pathway; Autophagy; Senescence; Mechanistic target of rapamycin; Biology; Context (archaeology); mTORC2; Cell biology; RPTOR; Cancer research; mTORC1; Signal transduction; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184361,0.0008447148,0.00105021,0.0008371921,0.001134857,0.004132257,0.0007236428,0.001642066,0.007626272],"category_scores_gemma":[0.0008800073,0.0003342856,0.0007569859,0.0005257991,0.001278117,0.002868918,0.001402228,0.003650386,0.001601207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009379976,"about_ca_system_score_gemma":0.001486892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004754696,"about_ca_topic_score_gemma":0.0009681111,"domain_scores_codex":[0.9994504,0.00008887005,0.000043462,0.0001198775,0.0001586663,0.0001386656],"domain_scores_gemma":[0.999569,0.00009223806,0.00007105825,0.00004302201,0.0001043789,0.000120315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005900083,0.0009805283,0.003075606,0.002435936,0.0003933431,0.002242883,0.0005182404,0.002216651,0.4682281,0.09728089,0.03274022,0.3839875],"study_design_scores_gemma":[0.00081942,0.004852723,0.008279053,0.0008146009,0.0006226116,0.003653766,0.001003316,0.005656948,0.3993933,0.051499,0.5231688,0.0002364997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.348552,0.4247377,0.0359918,0.07794134,0.009674379,0.000518852,0.002002132,0.002489993,0.09809177],"genre_scores_gemma":[0.8190706,0.1224589,0.01610391,0.009320081,0.002357286,0.0002306052,0.000669383,0.0002590623,0.02953007],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007626272,"threshold_uncertainty_score":0.0255124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08818198106284784,"score_gpt":0.463085141404584,"score_spread":0.3749031603417362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}