{"id":"W3136705796","doi":"10.4049/jimmunol.2000852","title":"Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Elafin; Inflammation; Downregulation and upregulation; Ccaat-enhancer-binding proteins; Immunology; Biology; Chemistry; Gene; Molecular biology; Cell biology; Genetics; Transcription factor; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001512518,0.0002283995,0.0001490923,0.0002153934,0.000108622,0.0002316944,0.00005884722,0.0001604168,0.001399667],"category_scores_gemma":[0.0001845213,0.00007631941,0.0001242326,0.0001772435,0.0001246333,0.0001351624,0.0001348853,0.0001838436,0.0002918396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000122703,"about_ca_system_score_gemma":0.0001058406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003185135,"about_ca_topic_score_gemma":0.0002296348,"domain_scores_codex":[0.9998926,0.00001860924,0.0000116356,0.0000246164,0.0000234601,0.00002897878],"domain_scores_gemma":[0.9998798,0.00002371867,0.00004641994,0.00001138093,0.00001919276,0.00001945266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002214682,0.00001533888,0.001813239,0.00004272933,0.000003766295,0.00009098204,0.00003547762,0.00001572824,0.9959906,0.00002882121,0.00002005273,0.001721854],"study_design_scores_gemma":[0.00003808423,0.0007074032,0.08204588,0.00002608301,0.00004179732,0.001734257,0.0002045966,0.0006401182,0.910305,0.0001719564,0.004076099,0.000008790033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932936,0.002752902,0.002832046,0.00004444423,0.00001387753,0.00003776454,0.0004496071,0.0000252633,0.0005505116],"genre_scores_gemma":[0.9961169,0.0007045136,0.001429754,0.00003186231,0.000009782909,0.00004334118,0.0004653199,0.00000391833,0.001194672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399667,"threshold_uncertainty_score":0.004682362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146831933692193,"score_gpt":0.2278677943569249,"score_spread":0.216399475020003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}