{"id":"W3136744096","doi":"10.1101/2021.03.23.436530","title":"Generation of functional ciliated cholangiocytes from human pluripotent stem cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children; Stem Cell Network; University Health Network","funders":"Japan Society for the Promotion of Science; Canada First Research Excellence Fund; Hospital for Sick Children; University of Toronto; Government of Canada; Genome Canada; Ontario Genomics; Ontario Genomics Institute; Cystic Fibrosis Canada","keywords":"Cholangiocyte; Induced pluripotent stem cell; Cilium; Bile duct; Biology; Stem cell; Transplantation; Cell biology; Cancer research; Neuroscience; Medicine; Pathology; Embryonic stem cell; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004565238,0.0002319486,0.0001333747,0.0002219988,0.0001539522,0.0003112692,0.0001487678,0.0002921904,0.003221747],"category_scores_gemma":[0.0002536091,0.0001629226,0.0002101326,0.0001886053,0.0002023163,0.0001523263,0.0003488323,0.0005337427,0.001369151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276014,"about_ca_system_score_gemma":0.0001858035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002295155,"about_ca_topic_score_gemma":0.0002826096,"domain_scores_codex":[0.9998552,0.00002450163,0.00002205895,0.00002111502,0.00006007469,0.00001705997],"domain_scores_gemma":[0.9998792,0.00003610425,0.00001366244,0.00002742494,0.0000249801,0.00001853567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004857056,0.00001270533,0.0002112364,0.00007675658,0.000008560027,0.0001349844,0.00003358774,0.0003465925,0.9923734,0.001715407,0.0006195307,0.004418673],"study_design_scores_gemma":[0.00005315726,0.0001196016,0.001486951,0.00002017818,0.00001938131,0.0003758254,0.00002635287,0.003043431,0.963496,0.0009386335,0.03041127,0.000009158803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7056677,0.003855895,0.241815,0.00126821,0.001038538,0.001119212,0.01607253,0.001444411,0.02771842],"genre_scores_gemma":[0.8993872,0.001837306,0.06728897,0.0003387079,0.00006968986,0.0003880869,0.01406871,0.0002299823,0.01639137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003221747,"threshold_uncertainty_score":0.01077783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505579941173338,"score_gpt":0.2157144182013341,"score_spread":0.1906586187896007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}