{"id":"W3136829774","doi":"10.1007/s00401-021-02291-6","title":"Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"LEO Pharma; National Cancer Institute; KWF Kankerbestrijding; Brain Tumour Charity; Cancer Research UK","keywords":"IDH1; DNA methylation; Astrocytoma; Methylation; Mutation; Cancer research; Isocitrate dehydrogenase; DNA; Biology; Medicine; Genetics; Glioma; Gene; Enzyme; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000276582,0.0003353663,0.0006514625,0.0002692646,0.0002126153,0.0000888846,0.00009566871,0.0001284302,0.00005758624],"category_scores_gemma":[0.001401517,0.0002748801,0.0000869417,0.001017099,0.00009240888,0.0001388259,0.00009645591,0.0002810744,0.0000167359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390098,"about_ca_system_score_gemma":0.0001405873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000090519,"about_ca_topic_score_gemma":0.0006574914,"domain_scores_codex":[0.9977094,0.0003734014,0.0004576533,0.0007098626,0.0003266599,0.0004230554],"domain_scores_gemma":[0.9981182,0.0005899407,0.0002449552,0.0004063746,0.0003500748,0.0002905065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002755554,0.001595784,0.4025711,0.0000273266,0.0001156094,0.004512339,0.0005796898,0.0001178109,0.5893065,0.00002776396,0.0001256773,0.0007448729],"study_design_scores_gemma":[0.004526704,0.0007437987,0.9630601,0.0001314913,0.0002892509,0.00018118,0.0006684836,0.0008124978,0.02919049,0.00004020607,0.0001018273,0.0002539194],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958851,0.00007723992,0.00008829372,0.002270276,0.00009326627,0.0008896549,0.0001553242,0.0001290613,0.0004118121],"genre_scores_gemma":[0.9969538,0.00002464915,0.001273336,0.0006448644,0.00003975043,0.0002381722,0.000757571,0.00004322592,0.00002465821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5604891,"threshold_uncertainty_score":0.9999703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341665053246516,"score_gpt":0.2676698937642086,"score_spread":0.2442532432317434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}