{"id":"W3136840304","doi":"10.1093/nar/gkab194","title":"Effect of small molecule eRF3 degraders on premature termination codon readthrough","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; E-Rare","keywords":"Nonsense mutation; Biology; Nonsense-mediated decay; Stop codon; Mutation; Genetics; Molecular biology; RNA; Gene; RNA splicing; Missense mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155369,0.0003307866,0.0003765449,0.0001381597,0.00009853451,0.0002202575,0.0001463694,0.0002137279,0.001223347],"category_scores_gemma":[0.0001585612,0.0001018906,0.000259697,0.0001049259,0.0001116633,0.0001281926,0.0001240728,0.0003089766,0.0003193095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442307,"about_ca_system_score_gemma":0.0001477953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207081,"about_ca_topic_score_gemma":0.000632736,"domain_scores_codex":[0.9999076,0.00002240045,0.00001260878,0.00002091196,0.0000203458,0.00001601245],"domain_scores_gemma":[0.9998751,0.00003071224,0.00003243417,0.00001100642,0.0000180397,0.00003283427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004417962,0.00006476793,0.0001183303,0.00006510829,0.00001626042,0.00005394281,0.000008472513,0.00007253615,0.9967809,0.00003290941,0.0000596327,0.002285346],"study_design_scores_gemma":[0.00006816726,0.001199612,0.001474186,0.000005429325,0.00002350376,0.0002158632,0.000008361882,0.0003848687,0.9951792,0.000009453284,0.001425509,0.000005791736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953856,0.002003736,0.0008269063,0.00005216464,0.0000239042,0.00004010315,0.000275833,0.0001139387,0.001277987],"genre_scores_gemma":[0.9949929,0.001169199,0.001649675,0.00006308463,0.000009672513,0.00003332281,0.0005533175,0.00003092614,0.001497833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223347,"threshold_uncertainty_score":0.004092515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02742334742023878,"score_gpt":0.349433635460545,"score_spread":0.3220102880403062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}