{"id":"W3136857533","doi":"10.1016/j.celrep.2021.108845","title":"Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont; McMaster University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Associazione Italiana per la Ricerca sul Cancro; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation","keywords":"Chronic lymphocytic leukemia; Induced pluripotent stem cell; Cancer research; Trisomy; Lymphocytosis; Malignancy; Leukemia; Cancer; Stem cell; Cancer stem cell; Biology; Medicine; Immunology; Bioinformatics; Gene; Internal medicine; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849977,0.00009448802,0.0001287411,0.0003595863,0.00006529854,0.0002316782,0.00007355471,0.000161254,0.001673319],"category_scores_gemma":[0.0002452743,0.00006755345,0.0000862634,0.0003438613,0.0001045783,0.0001207928,0.0001651638,0.000160068,0.0001628579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150651,"about_ca_system_score_gemma":0.00009254459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004470718,"about_ca_topic_score_gemma":0.0007142713,"domain_scores_codex":[0.9999056,0.00001680794,0.00000962065,0.00001674778,0.00003323605,0.00001792036],"domain_scores_gemma":[0.9998962,0.00003046104,0.00003399889,0.000008542452,0.00001580052,0.00001495004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001610268,0.00006763439,0.1549175,0.0001448952,0.00005557105,0.0006412207,0.0002737591,0.001051945,0.76891,0.0005104613,0.0007532462,0.07106354],"study_design_scores_gemma":[0.0001187121,0.002551839,0.5526723,0.00004469163,0.0001796779,0.004333004,0.000535498,0.003705561,0.4224239,0.0005418275,0.01287547,0.00001750984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959807,0.0014606,0.0007919674,0.00007518077,0.000004042952,0.00002653013,0.0005216565,0.00003688117,0.001102361],"genre_scores_gemma":[0.9979107,0.0004458933,0.0005479436,0.00005585239,0.00000386315,0.00002029459,0.0005641373,0.000004095758,0.0004473084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673319,"threshold_uncertainty_score":0.00559777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147021620072726,"score_gpt":0.2794892119168126,"score_spread":0.2647870499095401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}