{"id":"W3136913962","doi":"10.3389/fmed.2021.620990","title":"Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19","year":2021,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Downregulation and upregulation; Angiotensin-converting enzyme 2; Angiotensin II; Renin–angiotensin system; Viral entry; Coronavirus; Receptor; Pathogenesis; Virus; Immunology; Medicine; Virology; Viral replication; Pharmacology; Coronavirus disease 2019 (COVID-19); Chemistry; Internal medicine; Disease; Gene; Blood pressure; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452069,0.0002803419,0.0006734732,0.0002777639,0.0001327055,0.0003631574,0.0004206685,0.0003224162,0.001595764],"category_scores_gemma":[0.0001204275,0.00009456644,0.0004640053,0.000146728,0.0001242692,0.000304044,0.0002291774,0.001306746,0.0003168713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003189,"about_ca_system_score_gemma":0.000217566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003073458,"about_ca_topic_score_gemma":0.00101674,"domain_scores_codex":[0.9999254,0.00001616097,0.000007183755,0.00001394526,0.00001819346,0.00001915655],"domain_scores_gemma":[0.9999728,0.000003394164,0.000005838891,0.000001652679,0.000004915339,0.00001144156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008925325,0.006166848,0.001153764,0.002807067,0.0006539121,0.001789592,0.0002260796,0.001451506,0.6065452,0.002081641,0.008427842,0.3597711],"study_design_scores_gemma":[0.009377023,0.06789505,0.02079805,0.0005802653,0.002413088,0.007776306,0.0004371542,0.01174761,0.6220689,0.002613719,0.2540709,0.0002218966],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8135012,0.1534267,0.01846057,0.002452601,0.001984899,0.000643205,0.0006357796,0.000587209,0.00830787],"genre_scores_gemma":[0.9378117,0.0429119,0.01120152,0.001410327,0.0003732405,0.0002925011,0.0007607166,0.00004334129,0.005194622],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001595764,"threshold_uncertainty_score":0.005338371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08886250290727192,"score_gpt":0.3987095543856159,"score_spread":0.309847051478344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}