{"id":"W3136939712","doi":"10.1002/cmdc.202100107","title":"A Series of 2‐((1‐Phenyl‐1H‐imidazol‐5‐yl)methyl)‐1H‐indoles as Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitors","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Krembil Foundation; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Chemistry; Penetrant (biochemical); Indoleamine 2,3-dioxygenase; Docking (animal); Pharmacology; Indole test; Stereochemistry; Structure–activity relationship; Combinatorial chemistry; Biochemistry; Medicine; In vitro; Tryptophan; Organic chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002144484,0.0004548301,0.0005944695,0.0001721465,0.0001711837,0.00008829617,0.0005579281,0.0002571725,0.0006698966],"category_scores_gemma":[0.002545482,0.0004491745,0.0003098208,0.001175499,0.0006089524,0.0003967873,0.0003733121,0.0003735341,0.0002025896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006917964,"about_ca_system_score_gemma":0.0003488537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000217652,"about_ca_topic_score_gemma":0.0000302036,"domain_scores_codex":[0.9968804,0.0001473816,0.0006488657,0.0009292993,0.0006892586,0.0007048142],"domain_scores_gemma":[0.9980692,0.0003528863,0.0002838001,0.0008275214,0.0001635394,0.0003031034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149085,0.0003123942,0.0001746265,0.0001922703,0.0000225996,0.0001718461,0.001031795,0.000007844992,0.9882327,0.002488842,0.004006911,0.003243259],"study_design_scores_gemma":[0.00135928,0.00009602055,0.0005610691,0.0001125396,0.00001233033,0.000122746,0.001594569,0.000014519,0.9849486,0.00247023,0.008235528,0.0004725496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978999,0.0007277532,0.00002689933,0.001509584,0.0004570962,0.0002678315,0.00004821157,0.0002115741,0.01775211],"genre_scores_gemma":[0.9937323,0.0001921315,0.0004513692,0.001402751,0.0002817054,0.00004462372,0.00002377269,0.00007684406,0.003794498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01473336,"threshold_uncertainty_score":0.999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542026926379457,"score_gpt":0.2527000280994199,"score_spread":0.2272797588356253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}