{"id":"W3136939712","doi":"10.1002/cmdc.202100107","title":"A Series of 2‐((1‐Phenyl‐1H‐imidazol‐5‐yl)methyl)‐1H‐indoles as Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitors","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Krembil Foundation; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Chemistry; Penetrant (biochemical); Indoleamine 2,3-dioxygenase; Docking (animal); Pharmacology; Indole test; Stereochemistry; Structure–activity relationship; Combinatorial chemistry; Biochemistry; Medicine; In vitro; Tryptophan; Organic chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009555131,0.0003078156,0.000208162,0.0001573687,0.0001273964,0.0001727469,0.0003303782,0.0001928522,0.0009879034],"category_scores_gemma":[0.00007713603,0.0000877167,0.0001838982,0.0001439372,0.000127228,0.0001419365,0.000145416,0.000298929,0.0003212812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024587,"about_ca_system_score_gemma":0.0002311774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000634725,"about_ca_topic_score_gemma":0.00232954,"domain_scores_codex":[0.9999604,0.000007239005,0.000002564973,0.000007472814,0.00001039292,0.0000119161],"domain_scores_gemma":[0.9999737,0.000002601723,0.000008561872,0.000002338459,0.000004527501,0.000008282306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004638318,0.0003494119,0.0008281638,0.0004864226,0.00003515991,0.0004197102,0.00007261918,0.005421859,0.9622334,0.001147158,0.001001202,0.02754098],"study_design_scores_gemma":[0.0005431945,0.01093666,0.01316734,0.0001065251,0.0001555066,0.001127488,0.0001131487,0.01559305,0.9079831,0.000427798,0.04977565,0.00007064826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585937,0.01941379,0.01147951,0.0003321309,0.0001646555,0.0002914741,0.0009417805,0.0002513342,0.008531589],"genre_scores_gemma":[0.9821561,0.005904209,0.007299734,0.0001172966,0.00002025172,0.00008240774,0.0005068905,0.00001241338,0.003900665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009879034,"threshold_uncertainty_score":0.003304899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542026926379457,"score_gpt":0.2527000280994199,"score_spread":0.2272797588356253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}