{"id":"W3137008892","doi":"10.1126/science.abd9191","title":"Processive RNA polymerization and promoter recognition in an RNA World","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ribozyme; Ligase ribozyme; RNA; RNA-dependent RNA polymerase; Processivity; Polymerase; Biology; RNA editing; RNA world hypothesis; Genetics; DNA; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002825395,0.0002085259,0.0001546693,0.0001680713,0.0002324795,0.0007583004,0.0003169864,0.0004102808,0.0008094307],"category_scores_gemma":[0.000694886,0.0002964527,0.0001823171,0.0001142467,0.0007796587,0.0007849688,0.0004551308,0.000673058,0.0005501707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859879,"about_ca_system_score_gemma":0.0003498561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001689879,"about_ca_topic_score_gemma":0.0002328606,"domain_scores_codex":[0.9998216,0.00002748969,0.000009065534,0.00006548996,0.00005439285,0.00002202391],"domain_scores_gemma":[0.9996475,0.0001312311,0.00009259335,0.00006006077,0.000026546,0.00004201255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006248828,0.00003007628,0.0009056006,0.00005489056,0.000003897132,0.0001482697,0.000102462,0.0009893883,0.9723784,0.01846416,0.00006402868,0.006796365],"study_design_scores_gemma":[0.00002256055,0.0001475554,0.001090829,0.000009738194,0.000008378403,0.0003880874,0.00006625957,0.005809182,0.9816918,0.005845606,0.004904416,0.00001544574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9173146,0.002072222,0.06812496,0.0004428095,0.00006954178,0.00002736891,0.00005300256,0.0003103525,0.01158512],"genre_scores_gemma":[0.9826417,0.0006197034,0.01462772,0.00007092478,0.00001913961,0.00002105668,0.00006341906,0.00004403606,0.001892382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008094307,"threshold_uncertainty_score":0.002707839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663682623523935,"score_gpt":0.2743331213581742,"score_spread":0.2576962951229348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}