{"id":"W3137031156","doi":"10.1164/rccm.202102-0509oc","title":"A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One <i>F508del</i> Allele","year":2021,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; BC Children's Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute for Health and Care Research","keywords":"Medicine; Ivacaftor; Cystic fibrosis; Tolerability; Confidence interval; Adverse effect; Cystic fibrosis transmembrane conductance regulator; Internal medicine; Pediatrics; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005051317,0.0002309036,0.001450712,0.0002044616,0.0000655185,0.00001735591,0.0002186828,0.00005181448,0.0000711121],"category_scores_gemma":[0.001703583,0.0001806693,0.00004377063,0.0006355515,0.001988572,0.0002232337,0.0002260722,0.0004315861,3.631426e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009276599,"about_ca_system_score_gemma":0.0002959306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002596384,"about_ca_topic_score_gemma":0.00003536979,"domain_scores_codex":[0.9969974,0.0003719178,0.0009103343,0.0003790595,0.0009881221,0.0003532122],"domain_scores_gemma":[0.9974758,0.0006940416,0.0003251319,0.000336516,0.000718087,0.0004504257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02713476,0.01523538,0.6270809,0.001907668,0.0009277419,0.006119172,0.003943479,0.000008450065,0.2114985,0.0003565823,0.000655774,0.1051316],"study_design_scores_gemma":[0.1127732,0.2749568,0.5092093,0.00598848,0.001949136,0.002533311,0.07760827,0.00001357776,0.009680752,0.0001184735,0.004464008,0.0007047114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882498,0.01086673,0.00009343318,0.0002245584,0.000009041593,0.0004332417,0.0000385197,0.000005009749,0.00007965513],"genre_scores_gemma":[0.9958919,0.0002130546,0.003251086,0.0004418216,0.0001382005,0.00001155316,0.000008101045,0.0000310485,0.00001321589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2597214,"threshold_uncertainty_score":0.7367482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03395468983028063,"score_gpt":0.3709813630120999,"score_spread":0.3370266731818193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}