{"id":"W3137031156","doi":"10.1164/rccm.202102-0509oc","title":"A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One <i>F508del</i> Allele","year":2021,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; BC Children's Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute for Health and Care Research","keywords":"Medicine; Ivacaftor; Cystic fibrosis; Tolerability; Confidence interval; Adverse effect; Cystic fibrosis transmembrane conductance regulator; Internal medicine; Pediatrics; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364938,0.001125782,0.002055069,0.0002986672,0.0004707423,0.0007080447,0.0007481442,0.001024437,0.00335042],"category_scores_gemma":[0.0008777559,0.0005168275,0.001209342,0.0002673061,0.0009875933,0.0008491437,0.0003110669,0.002975018,0.0007424293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006130709,"about_ca_system_score_gemma":0.001690084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121762,"about_ca_topic_score_gemma":0.003357473,"domain_scores_codex":[0.9994915,0.0002169417,0.00002544068,0.00008584772,0.00007214516,0.0001080938],"domain_scores_gemma":[0.9990786,0.0001451786,0.0002144931,0.00006803176,0.00007632963,0.0004172565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7429364,0.1090771,0.009258711,0.0008455861,0.0009945061,0.0005274541,0.0004399095,0.001562832,0.07742635,0.0002606621,0.002386306,0.05428428],"study_design_scores_gemma":[0.4191011,0.5556065,0.01810982,0.00003932519,0.0002551168,0.0003417106,0.0000910091,0.0006635626,0.003914273,0.00008583139,0.001760131,0.00003171074],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954246,0.0008847617,0.0004062894,0.0001385317,0.00007138675,0.001773187,0.000671158,0.00005383988,0.0005762629],"genre_scores_gemma":[0.9890723,0.001261597,0.002436273,0.0005675383,0.0001456588,0.003288043,0.001333275,0.00002935583,0.001865961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335042,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03395468983028063,"score_gpt":0.3709813630120999,"score_spread":0.3370266731818193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}