{"id":"W3137050964","doi":"10.1016/j.nbd.2021.105535","title":"Transduction of inflammation from peripheral immune cells to the hippocampus induces neuronal hyperexcitability mediated by Caspase-1 activation","year":2021,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Peripheral blood mononuclear cell; Microglia; Hippocampal formation; Inflammation; Biology; Immunology; Neuroscience; Cell biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465353,0.0004851001,0.0003483088,0.0001855873,0.0001411815,0.0003125848,0.0001118452,0.0002413013,0.0021797],"category_scores_gemma":[0.000105302,0.00007962015,0.0003678111,0.0001192199,0.0002280463,0.0002590748,0.0002564467,0.0007976419,0.0003309816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024521,"about_ca_system_score_gemma":0.0002082394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001557621,"about_ca_topic_score_gemma":0.0003461206,"domain_scores_codex":[0.9998253,0.00002132794,0.00002194967,0.0000439566,0.00003234881,0.00005523428],"domain_scores_gemma":[0.9999192,0.00001104304,0.00002756557,0.00001092896,0.0000104442,0.00002083629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001827054,0.00003486179,0.0001456054,0.00009994105,0.000006867901,0.00006976791,0.00001401367,0.00002634366,0.9982363,0.00004390101,0.00002544998,0.001114292],"study_design_scores_gemma":[0.00006109595,0.0009346905,0.006179922,0.00002825098,0.00003831456,0.0004737003,0.00007867923,0.00050249,0.9905154,0.0001331789,0.001049313,0.000005108097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886774,0.003676669,0.00491768,0.0002107561,0.0001022486,0.00008454145,0.000460206,0.0001052379,0.001765082],"genre_scores_gemma":[0.9944592,0.001634795,0.002511155,0.00009476388,0.00002258951,0.00006646369,0.0002714618,0.000008660034,0.0009309344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0021797,"threshold_uncertainty_score":0.007291853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723529039429192,"score_gpt":0.2274646950253313,"score_spread":0.2102294046310394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}