{"id":"W3137057543","doi":"10.1016/j.jtho.2021.10.014","title":"Postoperative Chemotherapy Use and Outcomes From ADAURA: Osimertinib as Adjuvant Therapy for Resected EGFR-Mutated NSCLC","year":2021,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Eli Lilly Japan; Merck Sharp and Dohme; Ono Pharmaceutical; Teijin Pharma; Daiichi-Sankyo; Taiho Pharmaceutical; Chugai Pharmaceutical; Roche; Novartis; Takeda Pharmaceutical Company; AbbVie; Merck; Spectrum Pharmaceuticals; Boehringer Ingelheim; Amgen; Pfizer; Bayer; Shire; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Osimertinib; Medicine; Oncology; Internal medicine; Chemotherapy; Adjuvant; Adjuvant chemotherapy; Epidermal growth factor receptor; Cancer; Erlotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656527,0.0001506944,0.0001974857,0.0002027318,0.0001682206,0.0005094398,0.0002157011,0.0003362074,0.001546284],"category_scores_gemma":[0.001378197,0.000109078,0.0008268314,0.0003061129,0.0001924478,0.0004554401,0.0003268415,0.0007198917,0.0001474319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004046051,"about_ca_system_score_gemma":0.0003890907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002260443,"about_ca_topic_score_gemma":0.006355923,"domain_scores_codex":[0.999805,0.00002909948,0.0000274972,0.00003137354,0.0000343227,0.00007265672],"domain_scores_gemma":[0.9991097,0.0001742064,0.0004272131,0.00003588123,0.00004960925,0.0002033411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004647189,0.0002073106,0.9784039,0.00006976928,0.0004571867,0.0002250482,0.00005301823,0.0005122838,0.0007787269,0.0001008051,0.0006596171,0.01388513],"study_design_scores_gemma":[0.00006763685,0.0007661106,0.9968454,0.00002860671,0.0003585485,0.0002227902,0.0001741063,0.0004639708,0.0002050331,0.0001095926,0.0007476639,0.00001038842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969376,0.001359391,0.00005113299,0.0001540262,0.00004033896,0.000004542857,0.0004090746,0.000002679895,0.001041355],"genre_scores_gemma":[0.9980885,0.0005090667,0.00002690972,0.00008884195,0.00004086933,0.000004798162,0.000757905,0.000002270533,0.0004807965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260443,"threshold_uncertainty_score":0.005172849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04007172802736948,"score_gpt":0.4578091412325619,"score_spread":0.4177374132051925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}