{"id":"W3137136187","doi":"10.1073/pnas.2016818118","title":"Lineage-specific selection and the evolution of virulence in the <i>Candida</i> clade","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Government of Canada","keywords":"Biology; Virulence; Candida dubliniensis; Gene; Candida albicans; Genetics; Genome; Lineage (genetic); Corpus albicans; Phylogenetics; Phenotype; Negative selection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003623646,0.0001581564,0.0001571606,0.0005105985,0.0004938944,0.0005851341,0.00029456,0.0003280891,0.0008889079],"category_scores_gemma":[0.0004009463,0.0001374002,0.0001552298,0.0003055501,0.0002189833,0.0001887265,0.0006439289,0.000544778,0.000232316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551903,"about_ca_system_score_gemma":0.0001981815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451544,"about_ca_topic_score_gemma":0.002533903,"domain_scores_codex":[0.9998012,0.00005518299,0.000011549,0.00005276149,0.00003605877,0.00004319812],"domain_scores_gemma":[0.9997656,0.00006362731,0.00007517626,0.00002665551,0.00002583051,0.00004303161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003606209,0.00003140828,0.05055007,0.00004517955,0.00003598238,0.0002023386,0.0005926415,0.0006472009,0.9337536,0.00105617,0.0001649172,0.0125599],"study_design_scores_gemma":[0.00004255341,0.0003590038,0.9325196,0.00007772092,0.0001025114,0.001554467,0.001338806,0.006114542,0.04452717,0.001225975,0.012059,0.0000787706],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982761,0.0003207319,0.0002873846,0.00003758072,0.000002881808,0.000004742348,0.0000688808,0.000007307329,0.0009943437],"genre_scores_gemma":[0.9985653,0.0002311747,0.0004759265,0.00006758298,0.000004782883,0.000006893122,0.0002201135,0.0000160291,0.0004123009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001451544,"threshold_uncertainty_score":0.002973735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02969168978273173,"score_gpt":0.3013258814327333,"score_spread":0.2716341916500015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}