{"id":"W3137167345","doi":"10.15252/embr.202052141","title":"PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Shandong First Medical University; Natural Science Foundation of Shandong Province; National Science Fund for Distinguished Young Scholars; China Postdoctoral Science Foundation; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; Fundamental Research Fund of Shandong University; National Natural Science Foundation of China; Shandong University","keywords":"Exocytosis; Protein tyrosine phosphatase; Lipid bilayer fusion; Phosphorylation; Tyrosine; Cell biology; Phosphatase; Secretion; Biology; Biochemistry; Chemistry; Biophysics; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003154742,0.0002379811,0.0003520056,0.000150236,0.0001967733,0.000790983,0.0004340145,0.0006146125,0.001058699],"category_scores_gemma":[0.0006552781,0.0002233009,0.0003394265,0.0001105833,0.0004545752,0.001016749,0.0005916822,0.001001041,0.0002151725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886816,"about_ca_system_score_gemma":0.0001746717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002970562,"about_ca_topic_score_gemma":0.0003290369,"domain_scores_codex":[0.9997804,0.00002648133,0.00002362583,0.00006496072,0.00005337645,0.00005119455],"domain_scores_gemma":[0.9996439,0.00009358179,0.00009382432,0.00004384848,0.00004759553,0.00007727883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004397172,0.00002751756,0.000548043,0.00002201911,0.000007210948,0.00008005153,0.00002344404,0.0000679778,0.9972053,0.0008205963,0.00003780512,0.0007202787],"study_design_scores_gemma":[0.000117289,0.0002428774,0.05208848,0.000008282183,0.00003308854,0.0004496182,0.00009231344,0.004860473,0.9403764,0.0007088523,0.001006271,0.00001615651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938176,0.0005532701,0.004048627,0.0002902952,0.00004394563,0.00001447496,0.0002077095,0.00004140264,0.0009825578],"genre_scores_gemma":[0.9978941,0.0001393369,0.0009191246,0.00004864896,0.00001787788,0.00001725028,0.0001910445,0.00001783867,0.0007549409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058699,"threshold_uncertainty_score":0.003545642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009612240333733405,"score_gpt":0.2477309179418925,"score_spread":0.2381186776081591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}