{"id":"W3137167345","doi":"10.15252/embr.202052141","title":"PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Shandong First Medical University; Natural Science Foundation of Shandong Province; National Science Fund for Distinguished Young Scholars; China Postdoctoral Science Foundation; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; Fundamental Research Fund of Shandong University; National Natural Science Foundation of China; Shandong University","keywords":"Exocytosis; Protein tyrosine phosphatase; Lipid bilayer fusion; Phosphorylation; Tyrosine; Cell biology; Phosphatase; Secretion; Biology; Biochemistry; Chemistry; Biophysics; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019377,0.0001558076,0.0001656547,0.000008774853,0.0001438665,0.00005858058,0.0000292172,0.00009179718,0.00009832691],"category_scores_gemma":[0.0000616706,0.0001406267,0.00005373614,0.00004752413,0.00008937665,0.00001259049,0.00006627913,0.00006698824,2.606339e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004498468,"about_ca_system_score_gemma":0.0000459131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001011402,"about_ca_topic_score_gemma":0.0002703446,"domain_scores_codex":[0.9990005,0.00002645072,0.0002549031,0.0004415807,0.0001091036,0.0001674238],"domain_scores_gemma":[0.9995285,0.00001484649,0.0001055467,0.000223505,0.00005937997,0.00006817646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003627291,0.00001039521,0.125095,0.00003023935,0.00002477431,0.0009594175,0.0001193389,0.000005321953,0.8730982,0.00005661694,0.00002644628,0.0005380048],"study_design_scores_gemma":[0.0004804933,0.000102771,0.2554081,0.00005312207,0.00005972723,0.003975855,0.0003249477,0.00007436904,0.7316872,0.00108676,0.006398319,0.0003483129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955753,0.003258984,0.0001276098,0.00008319913,0.0001696608,0.00009272717,0.000009440601,0.00001453873,0.000668558],"genre_scores_gemma":[0.9957476,0.0001982713,0.0006290035,0.00004663323,0.0001317584,0.000003348677,0.002705758,0.00001693791,0.0005207373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.141411,"threshold_uncertainty_score":0.5734591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009612240333733405,"score_gpt":0.2477309179418925,"score_spread":0.2381186776081591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}