{"id":"W3137215333","doi":"10.1101/2021.03.23.436637","title":"The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugs","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Innovative Medicines Initiative; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Wellcome Trust; Genentech; Bayer; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Druggability; Helicase; Computational biology; Coronavirus; Biology; Binding site; Transcription (linguistics); RNA; RNA polymerase; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Genetics; Viral replication; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Virus; Disease; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005203327,0.0005821735,0.000796116,0.0003682825,0.0005226917,0.001149613,0.0004019515,0.000405591,0.005832911],"category_scores_gemma":[0.0005143132,0.0003401288,0.0006985315,0.0005973154,0.0003166717,0.000862704,0.0006221282,0.001066532,0.001239367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006346192,"about_ca_system_score_gemma":0.0006739843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002721432,"about_ca_topic_score_gemma":0.004298253,"domain_scores_codex":[0.9997506,0.0000368287,0.0000163668,0.00005292132,0.0001020372,0.00004133964],"domain_scores_gemma":[0.9997249,0.00004356517,0.00009169659,0.00004330429,0.00005569764,0.00004090488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001087898,0.0002831347,0.04265445,0.0008846314,0.0003061754,0.0005635828,0.0001954381,0.01630342,0.8260399,0.004262508,0.02122808,0.08619085],"study_design_scores_gemma":[0.000420839,0.001379434,0.1415935,0.0004649754,0.0005046485,0.003882262,0.0008880887,0.08935151,0.5584015,0.01222943,0.1906553,0.0002284943],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156096,0.02072623,0.03165694,0.004066411,0.0002024296,0.0001555921,0.01321856,0.003935745,0.01042853],"genre_scores_gemma":[0.9455594,0.00599752,0.03422702,0.0007930261,0.00005058386,0.00006386166,0.01103121,0.0004426719,0.001834659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005832911,"threshold_uncertainty_score":0.01951301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05890735176820353,"score_gpt":0.3328401611071544,"score_spread":0.2739328093389508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}