{"id":"W3137228832","doi":"10.1158/1055-9965.epi-20-1635","title":"The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies","year":2021,"lang":"en","type":"review","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; Sontag Foundation; Cancer Prevention and Research Institute of Texas; World Health Organization","keywords":"Lung cancer; Genetic architecture; Biology; Genome-wide association study; Heritability; Genetic association; Genetics; Linkage disequilibrium; Lung cancer susceptibility; Cancer; Single-nucleotide polymorphism; Quantitative trait locus; Genotype; Oncology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006657954,0.0005255741,0.0006364122,0.001655118,0.0005888405,0.001261883,0.0005731674,0.000466207,0.001125174],"category_scores_gemma":[0.013457,0.0003172338,0.001061419,0.002740296,0.001157946,0.0005054905,0.00164228,0.0009603085,0.00007751674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003860632,"about_ca_system_score_gemma":0.0007397591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003139024,"about_ca_topic_score_gemma":0.005453142,"domain_scores_codex":[0.9932804,0.003759416,0.0005349317,0.00149022,0.0006602883,0.0002748276],"domain_scores_gemma":[0.9799548,0.01245238,0.004651174,0.002031673,0.0005266195,0.0003833837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001526735,0.00002357208,0.9840437,0.00007757781,0.002321946,0.000284186,0.000128127,0.001844167,0.003740424,0.0006551184,0.0001253966,0.006603148],"study_design_scores_gemma":[0.00001478569,0.00005712905,0.9897883,0.00002955475,0.001160589,0.0005288242,0.00008643564,0.004710678,0.0006967182,0.002661227,0.0002494076,0.00001634211],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9846661,0.00170086,0.01227355,0.0002782703,0.00001284199,0.00002183035,0.0003889318,0.00005923541,0.0005983609],"genre_scores_gemma":[0.997795,0.0001403626,0.001808355,0.00002786012,0.00001031848,0.000009849947,0.0001608486,0.000006468815,0.0000410781],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006657954,"threshold_uncertainty_score":0.03521109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05728605930400563,"score_gpt":0.3967216261274429,"score_spread":0.3394355668234373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}