{"id":"W3137362953","doi":"10.1186/s40478-021-01132-7","title":"Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Agencia Estatal de Investigación; Britton Fund; Centers for Disease Control and Prevention; National Institutes of Health; Fundació la Marató de TV3; National Institute on Aging; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria","keywords":"Gene isoform; Phenotype; Genotype; Biology; Valine; Molecular biology; Gene; Prion protein; Genetically modified mouse; In vivo; PRNP; Transgene; Genetics; Disease; Pathology; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801817,0.0001484986,0.0002164624,0.00004958323,0.00008651234,0.00001332472,0.0006126933,0.00005418105,0.00005897492],"category_scores_gemma":[0.0004237987,0.0001272661,0.00007338717,0.0003083002,0.0003096605,0.000009468106,0.0004688358,0.0001422731,0.000001780713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009174256,"about_ca_system_score_gemma":0.000269447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002024896,"about_ca_topic_score_gemma":0.00006756208,"domain_scores_codex":[0.9987835,0.0003008077,0.0003345993,0.0002752803,0.0001240054,0.0001817935],"domain_scores_gemma":[0.99785,0.00005255347,0.0002461927,0.001500076,0.0002480808,0.000103122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005669583,0.0004587804,0.05660893,0.00008411855,0.00003048625,0.00006748897,0.00007164797,0.0000849061,0.9394021,0.0006992109,0.00008463772,0.001840755],"study_design_scores_gemma":[0.004004517,0.002537644,0.6101329,0.000460303,0.0003880648,0.0001844096,0.00065181,0.000774878,0.314961,0.0006434785,0.06398908,0.001271943],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936488,0.003655071,0.00008579243,0.0004950489,0.00002640099,0.0002367029,0.0001142456,0.00001342804,0.001724456],"genre_scores_gemma":[0.9943599,0.003424814,0.001692998,0.0001471262,0.00001266081,0.00002886283,0.0001988959,0.00001916634,0.0001155419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6244411,"threshold_uncertainty_score":0.5189763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297123516768521,"score_gpt":0.2887639637328002,"score_spread":0.2590516120559481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}