{"id":"W3137380811","doi":"10.1007/s40266-021-00845-7","title":"A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Drugs & Aging","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Dementia; Placebo; Adverse effect; Randomized controlled trial; Clinical Dementia Rating; Montreal Cognitive Assessment; Internal medicine; Memory span; Cognition; Audiology; Disease; Psychiatry; Working memory; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000938197,0.000233968,0.0009254419,0.0001384553,0.0002110732,0.00005158948,0.0001572525,0.00007129046,0.00007469563],"category_scores_gemma":[0.0001305413,0.0001688844,0.0001535525,0.0003337358,0.0004082102,0.00008406548,0.000266454,0.0003001003,0.000001156624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002885552,"about_ca_system_score_gemma":0.000126218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002647515,"about_ca_topic_score_gemma":0.0006672465,"domain_scores_codex":[0.9973839,0.0009653375,0.0006744819,0.0004239267,0.000219976,0.0003323697],"domain_scores_gemma":[0.9984246,0.0008479697,0.0002168893,0.0002516409,0.000154755,0.0001040967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9461049,0.009652692,0.02997538,0.0001440585,0.001197572,0.0001119526,0.008115896,0.00004604561,0.00203389,0.00005102297,0.00001460597,0.002551927],"study_design_scores_gemma":[0.9872618,0.000416556,0.007048346,0.0005013539,0.0008150215,0.00002701414,0.001482784,0.0004386747,0.001762591,0.00004017023,0.00001876651,0.0001869263],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861341,0.009070218,0.00001682152,0.0002953981,0.0001432018,0.004165109,0.00007746585,0.00001290148,0.00008484137],"genre_scores_gemma":[0.9994639,0.0001320906,0.00001349779,0.00007092572,0.00002778626,0.0001311776,0.00003576825,0.00001889318,0.0001059623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04115683,"threshold_uncertainty_score":0.6886905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04021436554838352,"score_gpt":0.3341194451769695,"score_spread":0.293905079628586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}