{"id":"W3137380811","doi":"10.1007/s40266-021-00845-7","title":"A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Drugs & Aging","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Dementia; Placebo; Adverse effect; Randomized controlled trial; Clinical Dementia Rating; Montreal Cognitive Assessment; Internal medicine; Memory span; Cognition; Audiology; Disease; Psychiatry; Working memory; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001813466,0.001967095,0.003944283,0.0007108644,0.0007984084,0.001031618,0.001577614,0.002485671,0.004845543],"category_scores_gemma":[0.001548217,0.001073179,0.001357169,0.0005406116,0.002109647,0.001402511,0.0004115138,0.002968782,0.0008831212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008185121,"about_ca_system_score_gemma":0.002059275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539693,"about_ca_topic_score_gemma":0.002713451,"domain_scores_codex":[0.9994075,0.0002555641,0.00004571398,0.000136028,0.00005310653,0.0001020008],"domain_scores_gemma":[0.9988686,0.0003056022,0.000176058,0.0001192258,0.00008963983,0.000440729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9618433,0.02356725,0.0002782593,0.0003202101,0.0003817281,0.00004038933,0.00005795831,0.0001613196,0.005669022,0.00007464356,0.0002875405,0.007318454],"study_design_scores_gemma":[0.9127986,0.08529324,0.0009137857,0.000009631675,0.0001388186,0.000018424,0.00001654554,0.000173519,0.0003855989,0.00006221196,0.0001785314,0.00001107744],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894605,0.001925372,0.00106046,0.0004051413,0.0004125239,0.004634671,0.0005892778,0.0001395661,0.001372578],"genre_scores_gemma":[0.9858849,0.001939265,0.002247134,0.001269985,0.0004811823,0.004802594,0.0007823468,0.00003223293,0.002560376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004845543,"threshold_uncertainty_score":0.0162099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04021436554838352,"score_gpt":0.3341194451769695,"score_spread":0.293905079628586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}