{"id":"W3137427440","doi":"10.1001/jamaoncol.2021.0379","title":"Evolution of the Randomized Clinical Trial in the Era of Precision Oncology","year":2021,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; NOSM University; Kingston Health Sciences Centre; Thunder Bay Regional Health Sciences Centre","funders":"","keywords":"Medicine; Randomized controlled trial; Internal medicine; Surrogate endpoint; Breast cancer; Oncology; Clinical endpoint; Colorectal cancer; Cohort; Lung cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7043592,0.001598844,0.009549882,0.01109464,0.001949209,0.02014906,0.006473544,0.01427278,0.003841168],"category_scores_gemma":[0.8001654,0.00229432,0.005072177,0.01624016,0.03496675,0.02984585,0.008311215,0.02159214,0.0009859994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01837224,"about_ca_system_score_gemma":0.02920063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002899943,"about_ca_topic_score_gemma":0.002066212,"domain_scores_codex":[0.2096371,0.6765438,0.05084325,0.01912658,0.04252733,0.001321853],"domain_scores_gemma":[0.06764428,0.8466977,0.0288158,0.0307783,0.02408088,0.001983181],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005905099,0.0003756392,0.02191906,0.04133962,0.0078139,0.000319898,0.005140611,0.005962398,0.000898763,0.4411921,0.02879954,0.4403334],"study_design_scores_gemma":[0.00601271,0.004220798,0.01281998,0.106264,0.004149165,0.001209297,0.002436639,0.01804307,0.001640838,0.6337883,0.2086543,0.0007609248],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01012991,0.3944216,0.218418,0.344237,0.02098408,0.002676802,0.000866921,0.0004516947,0.007813977],"genre_scores_gemma":[0.2317989,0.1133502,0.4321446,0.1747463,0.03617417,0.008715068,0.0006364498,0.0007881443,0.001646219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2956408,"threshold_uncertainty_score":0.3645778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5062045424251019,"score_gpt":0.6209226704404257,"score_spread":0.1147181280153238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}