{"id":"W3137443677","doi":"10.3389/fcell.2021.641727","title":"Strength Through Unity: The Power of the Mega-Scaffold MACF1","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Cancer Research Society","keywords":"Cytoskeleton; Microtubule; Crosstalk; Cell biology; Biology; Cell polarity; Actin; Microfilament; Cell migration; Actin cytoskeleton; Scaffold protein; Cell; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003531447,0.0003399892,0.0008045197,0.00005884002,0.0001297512,0.00001352183,0.000648776,0.0006812264,0.00005046418],"category_scores_gemma":[0.00006766844,0.0001849633,0.0002577964,0.000282414,0.0006588204,0.000002149211,0.0008699604,0.0003975318,0.000003562281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003750808,"about_ca_system_score_gemma":0.0004965233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001622662,"about_ca_topic_score_gemma":0.00001303718,"domain_scores_codex":[0.9979079,0.0006173786,0.0004554623,0.000539771,0.00009733516,0.0003821884],"domain_scores_gemma":[0.9992517,0.00005966503,0.0001796697,0.0004274047,0.00003675152,0.00004485738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001696118,0.0006149641,0.02726274,0.003694289,0.002092498,0.00006607051,0.0007420208,4.718748e-7,0.003279158,0.0008907509,0.1093498,0.8518376],"study_design_scores_gemma":[0.0002810471,0.00008600362,0.00007143099,0.0003013892,0.00005881763,0.00007410411,0.0005001323,2.142367e-7,0.002745028,0.00009923708,0.9955364,0.0002461202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004816158,0.9902673,0.00004141127,0.00003405978,0.0007941526,0.0004204914,0.00006774092,0.0000032428,0.003555439],"genre_scores_gemma":[0.002324985,0.994032,0.001131529,0.0001196911,0.00005851986,0.00004934508,0.0004796054,0.00002574926,0.001778622],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8861867,"threshold_uncertainty_score":0.7542586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119278043952761,"score_gpt":0.2849575005397759,"score_spread":0.2637647201002483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}