{"id":"W3137447723","doi":"10.1021/acsptsci.1c00006","title":"Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7","year":2021,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Fonds De La Recherche Scientifique - FNRS; H2020 Marie Skłodowska-Curie Actions; Fonds National de la Recherche Luxembourg","keywords":"Scavenger receptor; Receptor; Adrenomedullin; Calcitonin gene-related peptide; Chemistry; G protein-coupled receptor; Calcitonin; Endocrinology; Biochemistry; Biology; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001569705,0.000222907,0.0001425733,0.000120551,0.000115881,0.0001931137,0.0001354726,0.0001921531,0.003255585],"category_scores_gemma":[0.0001107193,0.00004986634,0.0001741024,0.0000707045,0.0001248439,0.0001901497,0.0002025332,0.0004524064,0.0006683558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001496793,"about_ca_system_score_gemma":0.0001642426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242654,"about_ca_topic_score_gemma":0.0005981477,"domain_scores_codex":[0.9998769,0.00002657543,0.000009593109,0.00001862985,0.00002814464,0.00004028221],"domain_scores_gemma":[0.9999415,0.000008092185,0.00001816948,0.000006152612,0.000007250752,0.00001884276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00030522,0.00003346525,0.0004559442,0.00007956068,0.000006779401,0.0001361656,0.00001239581,0.0000782424,0.9933154,0.0003114303,0.0001994268,0.005066019],"study_design_scores_gemma":[0.00004631235,0.0009686471,0.01253125,0.00003759384,0.0000318366,0.001442346,0.00007082395,0.001153447,0.9672377,0.0005231685,0.0159391,0.00001781561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758542,0.009516724,0.00587551,0.0004928948,0.0002768108,0.00007920785,0.0009082259,0.0000849721,0.006911508],"genre_scores_gemma":[0.9840249,0.004205318,0.007446235,0.0004221863,0.00008456902,0.00005799161,0.0009101683,0.00001386281,0.00283467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003255585,"threshold_uncertainty_score":0.01089096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378631539791939,"score_gpt":0.300763608001354,"score_spread":0.2669772926034347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}