{"id":"W3137447723","doi":"10.1021/acsptsci.1c00006","title":"Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7","year":2021,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Fonds De La Recherche Scientifique - FNRS; H2020 Marie Skłodowska-Curie Actions; Fonds National de la Recherche Luxembourg","keywords":"Scavenger receptor; Receptor; Adrenomedullin; Calcitonin gene-related peptide; Chemistry; G protein-coupled receptor; Calcitonin; Endocrinology; Biochemistry; Biology; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834936,0.0001982809,0.0002533729,0.00007809262,0.0005419464,0.00003916947,0.0009604949,0.000064298,0.0007491039],"category_scores_gemma":[0.000165361,0.0001512676,0.0001282919,0.001193904,0.002265162,0.0003570493,0.000191922,0.000339158,0.00006805931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000334133,"about_ca_system_score_gemma":0.0005371459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003112067,"about_ca_topic_score_gemma":0.000006148503,"domain_scores_codex":[0.9975894,0.0002014265,0.0003754038,0.0007563017,0.0005839168,0.0004935148],"domain_scores_gemma":[0.998849,0.0002988043,0.0002372891,0.0002442265,0.0002410659,0.0001296025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006562493,0.0001926927,0.001146419,0.000020271,0.000005594281,0.00002797579,0.0001313241,0.0002827061,0.9953457,0.001124001,0.0006077125,0.001049992],"study_design_scores_gemma":[0.0004702442,0.0000643419,0.03040969,0.00002139956,0.00002375993,0.0001027822,0.00001829354,0.000205111,0.9581901,0.0006528419,0.00968089,0.0001605689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932994,0.0000830473,0.000009226112,0.004193936,0.0007639596,0.000260208,0.00008820929,0.00003104048,0.001271035],"genre_scores_gemma":[0.9960711,0.00006388553,0.0002736086,0.002710791,0.0002404763,0.00002300102,0.000004806843,0.00001514965,0.0005971759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03715561,"threshold_uncertainty_score":0.8346084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378631539791939,"score_gpt":0.300763608001354,"score_spread":0.2669772926034347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}