{"id":"W3137473376","doi":"10.1016/j.cell.2021.02.041","title":"Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Core Research for Evolutional Science and Technology; National Institute of General Medical Sciences; Université de Sherbrooke; Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Japan Science and Technology Agency; Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Allosteric regulation; Biology; G protein; Adenosine A2A receptor; Biophysics; Structural biology; Nuclear magnetic resonance spectroscopy; Biochemistry; Adenosine receptor; Signal transduction; Agonist; Receptor; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721484,0.000112671,0.0001824857,0.0001590024,0.0003265746,0.0007039687,0.0002707635,0.0002846509,0.002303859],"category_scores_gemma":[0.0003061213,0.000174895,0.0001386529,0.0001477621,0.0004369696,0.0006898255,0.000172298,0.0005399202,0.0003261176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005497972,"about_ca_system_score_gemma":0.000206529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007919155,"about_ca_topic_score_gemma":0.002266815,"domain_scores_codex":[0.9999464,0.000009164123,0.000002006589,0.00001216058,0.00001138008,0.00001897612],"domain_scores_gemma":[0.9999207,0.00003315899,0.00001471194,0.000008460094,0.000008034201,0.00001502825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003474319,0.00002561899,0.0009406094,0.00004145721,0.00001172451,0.0001658945,0.0001085225,0.001069504,0.9898137,0.00413084,0.0002283385,0.003116509],"study_design_scores_gemma":[0.0001170593,0.0005285962,0.06462928,0.00004992556,0.00007044703,0.001052261,0.001226804,0.05589905,0.8577996,0.01091173,0.007631712,0.00008348306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928825,0.0008718865,0.003565327,0.0004114382,0.0000192594,0.000006767792,0.00009193052,0.00003264457,0.002118327],"genre_scores_gemma":[0.9980458,0.0005164583,0.0006568533,0.00008812308,0.00001175115,0.000007405236,0.00009511509,0.00001515748,0.0005633862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002303859,"threshold_uncertainty_score":0.007707179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0060585543396144,"score_gpt":0.1971349092627096,"score_spread":0.1910763549230952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}