{"id":"W3137473376","doi":"10.1016/j.cell.2021.02.041","title":"Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Core Research for Evolutional Science and Technology; National Institute of General Medical Sciences; Université de Sherbrooke; Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Japan Science and Technology Agency; Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Allosteric regulation; Biology; G protein; Adenosine A2A receptor; Biophysics; Structural biology; Nuclear magnetic resonance spectroscopy; Biochemistry; Adenosine receptor; Signal transduction; Agonist; Receptor; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342722,0.00006726173,0.00006568046,0.000006512166,0.0001362621,0.00001831441,0.000134855,0.0000558748,0.0002076118],"category_scores_gemma":[0.00005277292,0.00004152944,0.00006804207,0.00006321884,0.00002117361,0.000002466595,0.00009821898,0.00007495409,0.00000450143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004052969,"about_ca_system_score_gemma":0.00006642073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002332569,"about_ca_topic_score_gemma":0.000002021802,"domain_scores_codex":[0.9994782,0.0000204077,0.0001734269,0.0001086489,0.0001132721,0.0001060313],"domain_scores_gemma":[0.9995664,0.000008719826,0.00009715345,0.000187747,0.0001211244,0.00001887531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009010011,0.00001132135,0.0001633608,0.00002853493,0.000008830524,1.981064e-7,0.00005889165,0.001342016,0.9981045,0.00005730392,0.0001656294,0.00005045935],"study_design_scores_gemma":[0.0002235596,0.00001499807,0.0001061408,0.00002932367,0.000005644401,0.000003630276,0.0003318017,0.001355971,0.9947683,0.00001266785,0.003090272,0.00005770788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997214,0.0007901773,0.0009761048,0.0001441495,0.0001190298,0.0001152484,0.000008570127,0.000003702984,0.0006290152],"genre_scores_gemma":[0.9975601,0.00002947575,0.0007472753,0.00006564573,0.0001946482,0.00001020636,0.00004463851,0.000009131594,0.001338922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003336161,"threshold_uncertainty_score":0.2273204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0060585543396144,"score_gpt":0.1971349092627096,"score_spread":0.1910763549230952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}