{"id":"W3137525546","doi":"10.7554/elife.58565","title":"Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; National Institutes of Health; Max-Planck-Gesellschaft; Alzheimer’s Research UK; European Commission; Alzheimer's Society; UK Dementia Research Institute; Alzheimer Society; Wellcome Trust; Medical Research Council; Wellcome","keywords":"C9orf72; Trinucleotide repeat expansion; Biology; Amyotrophic lateral sclerosis; Frontotemporal dementia; Insulin; Phenotype; Insulin receptor; Cell biology; Drosophila melanogaster; Neurodegeneration; Genetics; Gene; Internal medicine; Endocrinology; Dementia; Medicine; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004286942,0.0002026262,0.0004541705,0.0001418386,0.00008879276,0.00004913196,0.0001352853,0.0001613696,0.0007073936],"category_scores_gemma":[0.0007571108,0.0001799955,0.000111818,0.0007364224,0.00008039518,0.0001511215,0.0001802947,0.0005453054,0.0002798688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159598,"about_ca_system_score_gemma":0.0002669004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129036,"about_ca_topic_score_gemma":0.00007180612,"domain_scores_codex":[0.9974977,0.0001698754,0.0004980784,0.0005579019,0.0007652199,0.0005112123],"domain_scores_gemma":[0.998768,0.0001207791,0.00007296286,0.0004501432,0.0003140582,0.0002740183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007772,0.0002379165,0.004060876,0.00005597841,0.00002031245,0.000476573,0.0003431194,0.0002056074,0.9905307,0.00004249774,0.0003480209,0.003477643],"study_design_scores_gemma":[0.001835323,0.000204898,0.182721,0.0005503509,0.00001404179,0.00002501977,0.0001487815,0.001173575,0.8124185,0.0001623293,0.0005195393,0.0002266209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940917,0.0007953672,0.0002259715,0.003021256,0.0001103289,0.0002993544,0.000004284139,0.00009650599,0.001355213],"genre_scores_gemma":[0.9944826,0.001129903,0.001409017,0.00156521,0.0003350411,0.00002872608,0.00004100769,0.00004173167,0.0009667709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1786602,"threshold_uncertainty_score":0.7745464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03182479601313074,"score_gpt":0.3022337698853816,"score_spread":0.2704089738722509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}