{"id":"W3137562009","doi":"10.1016/j.bioorg.2021.104844","title":"Ginsenoside derivatives inhibit advanced glycation end-product formation and glucose–fructose mediated protein glycation in vitro via a specific structure–activity relationship","year":2021,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Concordia University; University of Alberta","funders":"","keywords":"Glycation; Chemistry; Ginseng; Ginsenoside; Advanced glycation end-product; Fructosamine; Bovine serum albumin; Biochemistry; Fructose; In vitro; Maillard reaction; Receptor; Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732809,0.000674661,0.0004167423,0.0002631741,0.000162901,0.0002623258,0.0002095156,0.0002305061,0.001090772],"category_scores_gemma":[0.0001685185,0.0002223884,0.0004375381,0.0002668201,0.0002153537,0.0001888277,0.0001496478,0.0005089811,0.0004175882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002782505,"about_ca_system_score_gemma":0.0002401228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001060068,"about_ca_topic_score_gemma":0.001884363,"domain_scores_codex":[0.9998649,0.00003818962,0.00001355311,0.00001547725,0.00002410933,0.00004369144],"domain_scores_gemma":[0.9999192,0.00002334569,0.00002011162,0.00001300273,0.000007614469,0.00001664086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010184,0.0002611004,0.0002288977,0.00004541631,0.00003928366,0.00008028629,0.0000116329,0.0002508888,0.994688,0.0001440825,0.0001016762,0.003138542],"study_design_scores_gemma":[0.00006006003,0.001082469,0.001658456,0.000002576619,0.00003617049,0.0001027854,0.000006211887,0.000466623,0.9957123,0.00002433811,0.0008437321,0.000004207785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914243,0.003216161,0.002148713,0.0001132257,0.00008175088,0.00007724209,0.0003144339,0.00008894088,0.002535209],"genre_scores_gemma":[0.9934351,0.001985071,0.00152076,0.00005428923,0.00002605104,0.00003456611,0.0006553449,0.00001619926,0.002272636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090772,"threshold_uncertainty_score":0.003648996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379222086871639,"score_gpt":0.2532414633044178,"score_spread":0.2394492424357014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}