{"id":"W3137562009","doi":"10.1016/j.bioorg.2021.104844","title":"Ginsenoside derivatives inhibit advanced glycation end-product formation and glucose–fructose mediated protein glycation in vitro via a specific structure–activity relationship","year":2021,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Concordia University; University of Alberta","funders":"","keywords":"Glycation; Chemistry; Ginseng; Ginsenoside; Advanced glycation end-product; Fructosamine; Bovine serum albumin; Biochemistry; Fructose; In vitro; Maillard reaction; Receptor; Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000203628,0.00025443,0.0001977192,0.00006560008,0.0001432296,0.00004886206,0.0001472145,0.0002036446,0.00008597998],"category_scores_gemma":[0.001324915,0.0002883586,0.00003708994,0.0006073499,0.0001276845,0.0000741888,0.0001424486,0.0002997714,0.000007856989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001685663,"about_ca_system_score_gemma":0.0002431632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008228319,"about_ca_topic_score_gemma":0.00002221241,"domain_scores_codex":[0.9981217,0.0001330574,0.000370979,0.0007795318,0.0002784247,0.0003163446],"domain_scores_gemma":[0.9986891,0.00004905289,0.0002261532,0.0006271593,0.0002994195,0.0001090931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438319,0.00007535089,0.0003554501,0.0001389229,0.00001268085,0.000003702906,0.0001324759,0.00001846506,0.9872757,0.00001688979,0.0000272387,0.01169929],"study_design_scores_gemma":[0.000930491,0.00002389242,0.008872108,0.00002976646,0.000005514283,0.00006346721,0.000132507,0.00007949366,0.986678,0.0004769582,0.002413422,0.0002943869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930319,0.002337588,0.003003311,0.0008712144,0.0000436729,0.0004781323,0.00005327991,0.00003788626,0.0001430055],"genre_scores_gemma":[0.9938185,0.000321255,0.00319607,0.00003367634,0.0001973212,0.00005692576,0.0019879,0.00003975149,0.000348615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0114049,"threshold_uncertainty_score":0.9999568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379222086871639,"score_gpt":0.2532414633044178,"score_spread":0.2394492424357014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}