{"id":"W3137566103","doi":"10.1016/j.eururo.2021.02.041","title":"Untangling the PROfound Trial for Advanced Prostate Cancer: Is There Really a Role for Olaparib?","year":2021,"lang":"en","type":"editorial","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Arnold Ventures","keywords":"Olaparib; Medicine; PARP inhibitor; Prostate cancer; Homologous recombination; Oncology; Clinical endpoint; Internal medicine; Prostate; Gene; Cancer; Randomized controlled trial; Poly ADP ribose polymerase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02143333,0.003504831,0.003985396,0.001946005,0.002315697,0.00629779,0.004356258,0.02188975,0.005563735],"category_scores_gemma":[0.03842768,0.001368964,0.003351279,0.001298363,0.002552249,0.00570124,0.00109051,0.03724676,0.007351496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003258208,"about_ca_system_score_gemma":0.003870282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001898529,"about_ca_topic_score_gemma":0.004445342,"domain_scores_codex":[0.9932943,0.002010805,0.000914538,0.0006017949,0.002828921,0.0003496685],"domain_scores_gemma":[0.9677416,0.02133493,0.001361905,0.000624957,0.006119993,0.002816592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002431843,0.00002574916,0.00003588047,0.0005433708,0.00006651042,0.0001310466,0.00002256305,0.00003986006,0.0000975162,0.0006875309,0.9866176,0.0114892],"study_design_scores_gemma":[0.0008238479,0.000223742,0.0005826784,0.001505624,0.0002954893,0.0003229843,0.00005327388,0.0004303746,0.0002976268,0.003797582,0.9916077,0.00005909459],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001010691,0.01697739,0.0002817503,0.07613204,0.9045398,0.00006044479,0.0001219931,0.0001207802,0.001664742],"genre_scores_gemma":[0.0008371469,0.01068491,0.0003239642,0.09651664,0.8837053,0.00008343327,0.00006628588,0.00007662205,0.007705792],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02188975,"threshold_uncertainty_score":0.1133517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02221300169980072,"score_gpt":0.3445303999727195,"score_spread":0.3223173982729188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}