{"id":"W3137568497","doi":"10.1158/1541-7786.mcr-20-1040","title":"Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Wallonie-Bruxelles International; Amis de l'Institut Bordet","keywords":"Microphthalmia-associated transcription factor; Dasatinib; Melanoma; Cancer research; CREB; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Protein kinase B; Transcription factor; Kinase; Phosphorylation; Biology; Chemistry; Signal transduction; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006919639,0.0002009977,0.0004237556,0.0001748845,0.0001673699,0.00003031448,0.0003021481,0.0002083793,0.001799338],"category_scores_gemma":[0.0002575892,0.0001590148,0.00005389149,0.0007486451,0.0001960365,0.000056262,0.000182896,0.000633893,0.00002356084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141585,"about_ca_system_score_gemma":0.0006211198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006742328,"about_ca_topic_score_gemma":0.00216314,"domain_scores_codex":[0.9975012,0.000630971,0.0003812298,0.0005739103,0.0002313151,0.0006814034],"domain_scores_gemma":[0.9986919,0.0002661802,0.0001234394,0.0004494276,0.0004205199,0.00004855339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009760549,0.0001752177,0.0001220826,0.0001980646,0.000127273,0.0003973354,0.0006636483,0.00002301284,0.9911158,0.003867275,0.0002605804,0.002073664],"study_design_scores_gemma":[0.002037123,0.0003070855,0.000133404,0.0003363932,0.000007556832,0.00001555537,0.0005947051,0.00002061343,0.9706933,0.0001882112,0.0254645,0.0002014912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841924,0.01015312,0.000874548,0.0006761135,0.00008643538,0.000519405,0.0002119275,0.00002600967,0.003260061],"genre_scores_gemma":[0.9843388,0.0002741727,0.0002054744,0.00006726075,0.0000108141,0.0001453553,0.00008932078,0.00004131367,0.01482747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02520392,"threshold_uncertainty_score":0.9991131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813668441691048,"score_gpt":0.3159170113431797,"score_spread":0.2777803269262692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}