{"id":"W3137568497","doi":"10.1158/1541-7786.mcr-20-1040","title":"Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Wallonie-Bruxelles International; Amis de l'Institut Bordet","keywords":"Microphthalmia-associated transcription factor; Dasatinib; Melanoma; Cancer research; CREB; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Protein kinase B; Transcription factor; Kinase; Phosphorylation; Biology; Chemistry; Signal transduction; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006174274,0.0001779647,0.0002228071,0.000114145,0.00009785079,0.0001994743,0.0001050453,0.0001640266,0.001649152],"category_scores_gemma":[0.0000775719,0.00006260862,0.0002279122,0.0001058372,0.0001058094,0.0001373739,0.0001011885,0.0005673178,0.0002547683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855255,"about_ca_system_score_gemma":0.0001363392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002953925,"about_ca_topic_score_gemma":0.0006366255,"domain_scores_codex":[0.9998949,0.0000195552,0.000009846843,0.00001518786,0.0000321863,0.0000283062],"domain_scores_gemma":[0.9999744,0.000005037571,0.000004739831,0.000004754617,0.000004643599,0.000006395829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002249091,0.00004877848,0.0003829822,0.00009690042,0.00001364479,0.0001057211,0.00001400262,0.00009630941,0.995007,0.0001117815,0.0001747788,0.003723211],"study_design_scores_gemma":[0.00006616134,0.0005762993,0.005908177,0.000004663063,0.00002605875,0.0008734681,0.00003563083,0.0008776183,0.9859461,0.0001073535,0.005573531,0.000004783145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888169,0.005146621,0.002551974,0.000332993,0.0000809574,0.00005008843,0.0004952864,0.000143034,0.00238217],"genre_scores_gemma":[0.9969987,0.0007986834,0.0004830961,0.00004779232,0.000007171546,0.00002066586,0.0002469195,0.000006840455,0.001390249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649152,"threshold_uncertainty_score":0.005516946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813668441691048,"score_gpt":0.3159170113431797,"score_spread":0.2777803269262692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}