{"id":"W3137608926","doi":"10.1158/2326-6066.cir-20-0800","title":"Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions","year":2021,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Institute of Health Services and Policy Research; Deutsche Forschungsgemeinschaft; Rosetrees Trust; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Institutes of Health Research; Melanoma Research Alliance; International Development Research Centre; Government of Canada; Azrieli Foundation; Israel Science Foundation; Israel Cancer Research Fund","keywords":"Cytotoxic T cell; Immune checkpoint; Cancer immunotherapy; Alternative splicing; Biology; Cancer research; Gene isoform; Cell biology; Immune system; T cell; splice; Receptor; Immunotherapy; Effector; Immunology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009819252,0.0002595846,0.0004572412,0.0002487556,0.0009801907,0.00003248921,0.0004127495,0.0003615767,0.002631648],"category_scores_gemma":[0.0005071693,0.0002003639,0.0003006823,0.000665652,0.0008787048,0.0001899033,0.0005780735,0.001725427,0.0008217545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005088081,"about_ca_system_score_gemma":0.0005711408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001721475,"about_ca_topic_score_gemma":0.00008521614,"domain_scores_codex":[0.9963645,0.001587933,0.0006436281,0.0005371314,0.0001328213,0.0007339854],"domain_scores_gemma":[0.996989,0.0007532499,0.0003211527,0.0006441348,0.001268213,0.00002430652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006628804,0.0002129568,0.0007664587,0.0000462025,0.0004767313,0.000004389979,0.001441615,0.00003035558,0.9888981,0.0001182844,0.005172921,0.002169125],"study_design_scores_gemma":[0.001753287,0.0003262417,0.003287794,0.0002995201,0.00004641207,0.00007665641,0.002362811,0.0000274082,0.9660823,0.00003248968,0.0255171,0.0001879779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579861,0.02548706,0.000175459,0.001113439,0.01057267,0.0005880687,0.00005055969,0.00003715215,0.003989503],"genre_scores_gemma":[0.9503244,0.001374851,0.00002400361,0.00008832198,0.0001743897,0.0002685455,0.0001727379,0.0000409723,0.04753176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04354226,"threshold_uncertainty_score":0.9999563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02815255834980017,"score_gpt":0.3100179988044744,"score_spread":0.2818654404546742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}