{"id":"W3137608926","doi":"10.1158/2326-6066.cir-20-0800","title":"Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions","year":2021,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Institute of Health Services and Policy Research; Deutsche Forschungsgemeinschaft; Rosetrees Trust; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Institutes of Health Research; Melanoma Research Alliance; International Development Research Centre; Government of Canada; Azrieli Foundation; Israel Science Foundation; Israel Cancer Research Fund","keywords":"Cytotoxic T cell; Immune checkpoint; Cancer immunotherapy; Alternative splicing; Biology; Cancer research; Gene isoform; Cell biology; Immune system; T cell; splice; Receptor; Immunotherapy; Effector; Immunology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435919,0.0002645472,0.0001424025,0.0001159107,0.00008330373,0.0002354434,0.0001430262,0.0002052128,0.001141593],"category_scores_gemma":[0.00009188009,0.00007423648,0.0001590715,0.0000714058,0.0001651979,0.0000928338,0.0001046265,0.0004644613,0.0004124408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973771,"about_ca_system_score_gemma":0.0001190572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001810164,"about_ca_topic_score_gemma":0.0002815362,"domain_scores_codex":[0.9998759,0.00002350535,0.00001363259,0.00002152523,0.00003441783,0.00003104382],"domain_scores_gemma":[0.9999205,0.00001490194,0.00001872245,0.00001105268,0.000009251345,0.00002556564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002938281,0.000007917293,0.0000556043,0.000005539927,0.000001190852,0.0000189783,0.000002409789,0.00002506947,0.9993373,0.00006264471,0.00001854956,0.0004353351],"study_design_scores_gemma":[0.0000183691,0.0002243122,0.0007739178,0.000002029511,0.00001210274,0.0003182813,0.000008846349,0.000836029,0.9956285,0.00003893322,0.002136903,0.000001861645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938764,0.0005193052,0.003656994,0.0000819187,0.00005331853,0.00002032513,0.0001803314,0.00009212862,0.001519217],"genre_scores_gemma":[0.9968165,0.0001751338,0.001700916,0.00004017857,0.00001355964,0.000009643307,0.0001328875,0.00001851533,0.001092793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141593,"threshold_uncertainty_score":0.003818929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02815255834980017,"score_gpt":0.3100179988044744,"score_spread":0.2818654404546742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}