{"id":"W3137643806","doi":"10.1101/gad.345397.120","title":"Identification and characterization of conserved noncoding <i>cis</i>-regulatory elements that impact <i>Mecp2</i> expression and neurological functions","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; U.S. Department of Defense; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; National Institute of Neurological Disorders and Stroke; American Heart Association; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"MECP2; Rett syndrome; Biology; Gene duplication; Non-coding RNA; Genetics; Conserved sequence; Regulation of gene expression; Regulatory sequence; Long non-coding RNA; RNA; microRNA; Identification (biology); Gene; Computational biology; Phenotype; Base sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144316,0.000295586,0.0002926708,0.0002295457,0.0001256044,0.0002149279,0.0002187197,0.0002383439,0.0008093494],"category_scores_gemma":[0.0002671561,0.00013254,0.0002854779,0.0001268079,0.0001871493,0.0001105034,0.0001723407,0.0004038742,0.0004120529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653503,"about_ca_system_score_gemma":0.0002782863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007179484,"about_ca_topic_score_gemma":0.00146687,"domain_scores_codex":[0.9998885,0.00001102847,0.000008593882,0.00003854891,0.00003302484,0.00002024],"domain_scores_gemma":[0.999739,0.00004897438,0.00009433759,0.00003015251,0.00003269627,0.00005487518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004347836,0.000006729601,0.0005121403,0.00002983241,0.000003317315,0.00008714313,0.000009715824,0.00005929071,0.9975588,0.00008840991,0.0000175222,0.001583508],"study_design_scores_gemma":[0.00001483915,0.0001826357,0.0319828,0.00002073829,0.00004097654,0.001333616,0.00004160726,0.001491149,0.9608002,0.0001387737,0.003939159,0.00001340045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785612,0.002577719,0.0152836,0.0001056026,0.00003798009,0.00005886063,0.001379816,0.0001174027,0.001877913],"genre_scores_gemma":[0.9814314,0.0008669831,0.01261831,0.000119212,0.00002404275,0.00003803544,0.002672939,0.00005632199,0.002172697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008093494,"threshold_uncertainty_score":0.002707541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348692967141362,"score_gpt":0.2304482527698067,"score_spread":0.216961323098393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}