{"id":"W3137643806","doi":"10.1101/gad.345397.120","title":"Identification and characterization of conserved noncoding <i>cis</i>-regulatory elements that impact <i>Mecp2</i> expression and neurological functions","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; U.S. Department of Defense; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; National Institute of Neurological Disorders and Stroke; American Heart Association; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"MECP2; Rett syndrome; Biology; Gene duplication; Non-coding RNA; Genetics; Conserved sequence; Regulation of gene expression; Regulatory sequence; Long non-coding RNA; RNA; microRNA; Identification (biology); Gene; Computational biology; Phenotype; Base sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176485,0.000141353,0.0001231649,0.0000361444,0.0001293325,0.00003099615,0.00005747673,0.00007958128,0.00001778891],"category_scores_gemma":[0.00001230479,0.0001345771,0.00003043115,0.00006574223,0.00004927102,0.00000760747,0.0001907916,0.00003629259,0.000001521586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007189892,"about_ca_system_score_gemma":0.0001040751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.619996e-7,"about_ca_topic_score_gemma":0.000006082294,"domain_scores_codex":[0.9990196,0.0000529607,0.0002758439,0.0003637051,0.0001347504,0.0001531279],"domain_scores_gemma":[0.9995666,0.000006306096,0.0001232062,0.0001560586,0.00007548882,0.00007236405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003477674,0.00004328218,0.06468481,0.00002166167,0.00002564556,0.000001645188,0.00006143555,0.000003844533,0.9248512,0.000001928749,0.00006079855,0.01020898],"study_design_scores_gemma":[0.0002347703,0.00003417165,0.4594375,0.000008194012,0.000006992821,0.00001303084,0.00003252712,0.00001451828,0.5374545,0.000004841842,0.002669085,0.00008987144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977841,0.0006630885,0.001176314,0.0000613587,0.0001245244,0.000142846,0.0000172078,0.000006969145,0.0000235478],"genre_scores_gemma":[0.9969358,0.001339261,0.0008965954,0.0001824678,0.0000104805,0.000024358,0.0004247969,0.00001354571,0.0001726563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3947527,"threshold_uncertainty_score":0.5487895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348692967141362,"score_gpt":0.2304482527698067,"score_spread":0.216961323098393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}