{"id":"W3137645650","doi":"10.1126/science.aaz4544","title":"WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Princess Margaret Cancer Centre; University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"PI3K/AKT/mTOR pathway; Cell biology; Autoimmunity; T cell; Biology; Actin cytoskeleton; Signal transduction; Conditional gene knockout; Cell; Cytoskeleton; Phenotype; Immune system; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496321,0.0004157236,0.000249534,0.0003917445,0.0001801362,0.0004363169,0.0003171225,0.0003775147,0.002314822],"category_scores_gemma":[0.00009789839,0.0001916711,0.0002203518,0.000190543,0.0003177068,0.000275043,0.0003025632,0.0009376889,0.0006470451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113237,"about_ca_system_score_gemma":0.000237307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002588234,"about_ca_topic_score_gemma":0.0009246578,"domain_scores_codex":[0.9998392,0.00002205018,0.00001508453,0.00002575323,0.00004965538,0.00004814825],"domain_scores_gemma":[0.9998925,0.00001372008,0.00003019334,0.00001350286,0.00001052551,0.00003963884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001363321,0.00004159829,0.0001853375,0.00003057616,0.000005734958,0.00004610698,0.00001028623,0.00007948647,0.9970856,0.0004698295,0.0001421085,0.001767021],"study_design_scores_gemma":[0.00007937093,0.0003714589,0.003872781,0.00001286544,0.00002566854,0.0003552621,0.00004425805,0.001716183,0.9854258,0.000191857,0.007897103,0.000007281053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826005,0.002103378,0.007832161,0.0004537332,0.000113457,0.00005731807,0.0007397626,0.000304717,0.005794858],"genre_scores_gemma":[0.9842297,0.001111918,0.003251903,0.0001779954,0.00004240246,0.00006828517,0.0007386535,0.00007323693,0.01030591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314822,"threshold_uncertainty_score":0.007743895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008364038848663847,"score_gpt":0.2371745170730337,"score_spread":0.2288104782243699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}