{"id":"W3137666435","doi":"10.1186/s12974-021-02126-x","title":"Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Peripheral Neuropathies and Disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Louise and Alan Edwards Foundation","keywords":"TLR4; Immunology; Medicine; Innate immune system; Immune system; Peripheral neuropathy; Pathogenesis; Myelin; Neuroscience; Biology; Central nervous system; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917057,0.0001194842,0.0003462455,0.0001591275,0.00002902866,0.00001656622,0.00003220731,0.00006688893,0.00001493374],"category_scores_gemma":[0.0002288318,0.0001150293,0.00008992122,0.0001567035,0.00004201872,0.0004494717,0.00002165177,0.000266764,1.741678e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002994685,"about_ca_system_score_gemma":0.0001231732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002141323,"about_ca_topic_score_gemma":0.00001754643,"domain_scores_codex":[0.998512,0.000182046,0.0007413424,0.000154051,0.0003033345,0.0001072711],"domain_scores_gemma":[0.9988341,0.000041196,0.0005803603,0.0001192402,0.0003601565,0.00006495813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001698379,0.0001620185,0.001313229,0.0001540618,0.000009018217,0.0001656746,0.0007076334,0.008982553,0.9845887,0.00001029734,0.00000331078,0.002205119],"study_design_scores_gemma":[0.003958427,0.0023791,0.1129683,0.0004413979,0.00008121144,0.0002518475,0.000697884,0.2790893,0.5997243,0.0002673531,0.000007883912,0.0001329953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986215,0.0001990704,0.000595597,0.0002530449,0.0000982938,0.0001813319,0.000007964904,0.000009125975,0.00003412138],"genre_scores_gemma":[0.9982856,0.0001057473,0.00142261,0.00005290922,0.00008784771,0.000001507849,0.00000784621,0.00001939031,0.00001657516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3848644,"threshold_uncertainty_score":0.4690758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187381702426132,"score_gpt":0.2408736175532638,"score_spread":0.2189998005290025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}