{"id":"W3137680077","doi":"10.3390/cancers13061434","title":"A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of Victoria","funders":"Centre Scientifique de Monaco","keywords":"Glutathione; Cancer cell; Cysteine; Cystine; Cell biology; In vivo; Chemistry; In vitro; Cell culture; Cancer research; Biology; Biochemistry; Cancer; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001411479,0.0002760473,0.0006054302,0.0001377317,0.00005078253,0.00003182019,0.0001485658,0.0001284577,0.0009291672],"category_scores_gemma":[0.00005811897,0.0002660485,0.0002082548,0.0005935814,0.00007989191,0.00007679923,0.00009894584,0.0002955864,0.0000743488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001612224,"about_ca_system_score_gemma":0.0008721094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008264541,"about_ca_topic_score_gemma":0.0001871771,"domain_scores_codex":[0.998026,0.00008748627,0.000457812,0.0005942032,0.0003459768,0.0004885463],"domain_scores_gemma":[0.9990136,0.00003528006,0.00009980718,0.0004974238,0.0001157997,0.0002380645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060141,0.000492965,0.4106133,0.001965921,0.0008113096,0.002581785,0.0039717,0.0006549102,0.5614064,0.0001189265,0.009319823,0.007002837],"study_design_scores_gemma":[0.01314694,0.002061234,0.1287231,0.004625867,0.0015409,0.0006147954,0.006439588,0.005723536,0.8169116,0.0001165488,0.01853183,0.00156414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877766,0.007777902,0.0000810251,0.0006494907,0.0005146863,0.0004362143,0.00002522305,0.00005960062,0.002679243],"genre_scores_gemma":[0.9934957,0.0006191158,0.0006899122,0.0006962736,0.0002488146,0.0001934944,0.00005573592,0.00005808032,0.00394285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2818902,"threshold_uncertainty_score":0.9999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019206516757148,"score_gpt":0.2580594669780401,"score_spread":0.2388529502208921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}